Gold-Speckled SPION@SiO 2 Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications.

Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

Original Publication: Weinheim, Germany : Wiley-VCH

Gold* ; Silicon Dioxide*; Asialoglycoprotein Receptor/*metabolism ; Carbohydrates/*chemistry ; Carcinoma, Hepatocellular/*diagnostic imaging ; Magnetic Iron Oxide Nanoparticles/*chemistry ; Metal Nanoparticles/*chemistry ; Sulfhydryl Compounds/*chemistry; Humans ; Liver Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging

Efforts are made to perform an early and accurate detection of hepatocellular carcinoma (HCC) by simultaneous exploiting multiple clinically non-invasive imaging modalities. Original nanostructures derived from the combination of different inorganic domains can be used as efficient contrast agents in multimodal imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) and Au nanoparticles (NPs) possess well-established contrasting features in magnetic resonance imaging (MRI) and X-ray computed tomography (CT), respectively. HCC can be targeted by using specific carbohydrates able to recognize asialoglycoprotein receptor 1 (ASGPR1) overexpressed in hepatocytes. Here, two different thiocarbohydrate ligands were purposely designed and alternatively conjugated to the surface of Au-speckled silica-coated SPIONs NPs, to achieve two original nanostructures that could be potentially used for dual mode targeted imaging of HCC. The results indicated that the two thiocarbohydrate decorated nanostructures possess convenient plasmonic/superparamagnetic properties, well-controlled size and morphology and good selectivity for targeting ASGPR1 receptor.
(© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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FontanApulia WOBV6K5 Italian Apulia Region; PRIN 2017 "NiFTy" Prot. 2017MYBTXC Italian Ministry for Research and Education (MIUR)

Keywords: ASGPR1 receptor; SPIONs; bioconjugates; gold/silica nanoparticles; thiocarbohydrate ligands

0 (ASGR1 protein, human)
0 (Asialoglycoprotein Receptor)
0 (Carbohydrates)
0 (Sulfhydryl Compounds)
7440-57-5 (Gold)
7631-86-9 (Silicon Dioxide)

Date Created: 20200707 Date Completed: 20210218 Latest Revision: 20210218

20240628

10.1002/chem.202002142

32628283