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Effect of Lactobacillus sakei, a Probiotic Derived from Kimchi, on Body Fat in Koreans with Obesity: A Randomized Controlled Study.

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  • المؤلفون: Lim S;Lim S; Moon JH; Moon JH; Shin CM; Shin CM; Jeong D; Jeong D; Kim B; Kim B
  • المصدر:
    Endocrinology and metabolism (Seoul, Korea) [Endocrinol Metab (Seoul)] 2020 Jun; Vol. 35 (2), pp. 425-434. Date of Electronic Publication: 2020 Jun 24.
  • نوع النشر :
    Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Korean Endocrine Society Country of Publication: Korea (South) NLM ID: 101554139 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2093-5978 (Electronic) Linking ISSN: 2093596X NLM ISO Abbreviation: Endocrinol Metab (Seoul) Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Seoul : Korean Endocrine Society, [2010]-
    • الموضوع:
      Adipose Tissue* ; Body Composition* ; Body Mass Index* ; Weight Loss*; Latilactobacillus sakei/*chemistry ; Obesity/*therapy ; Probiotics/*administration & dosage; Adult ; Aged ; Body Weight ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis ; Republic of Korea/epidemiology ; Young Adult
    • نبذة مختصرة :
      Background: The increased prevalence of obesity has led to increases in the prevalence of chronic diseases worldwide. There is interest whether probiotics have an effect on obesity, but the effectiveness and safety of only a few probiotics for the treatment of obesity have been reported. The purpose of this study was to investigate whether ingestion of Lactobacillus sakei (CJLS03) derived from kimchi causes weight loss in people with obesity.
      Methods: This randomized, double-blind, placebo-controlled, clinical trial involved 114 adults with a body mass index (BMI) ≥25 kg/m2 who were assigned randomly to a CJLS03 or placebo group. The groups received two allocations of either 5×109 colony-forming units of CJLS03/allocation or the equivalent vehicle for 12 weeks. Demographic and biochemical parameters, and body composition including fat and muscle mass were measured at baseline and after 12 weeks. Changes in body fat, weight, and waist circumference were compared between the two treatment groups. Adverse events were monitored during study period.
      Results: Body fat mass decreased by 0.2 kg in the CJLS03 group and increased by 0.6 kg in the placebo group (0.8 kg difference, P=0.018). After the 12 weeks, waist circumference was 0.8 cm smaller in the CJLS03 group than in the placebo group (P=0.013). BMI and body weight did not change after the 12 weeks. Adverse events were mild and did not differ between the two groups.
      Conclusion: These data suggest that L. sakei (CJLS03) might help people with obesity reduce body fat mass without serious side effects (ClinicalTrials.gov: NCT03248414).
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    • Contributed Indexing:
      Keywords: Body fat; Obesity; Probiotics; Lactobacillus sakei
    • Molecular Sequence:
      ClinicalTrials.gov NCT03248414
    • الموضوع:
      Date Created: 20200704 Date Completed: 20210611 Latest Revision: 20221207
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC7386112
    • الرقم المعرف:
      10.3803/EnM.2020.35.2.425
    • الرقم المعرف:
      32615727