Risk factors for aggressive recurrent respiratory papillomatosis in Chinese juvenile patients.

Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-2251 (Electronic) Linking ISSN: 00016489 NLM ISO Abbreviation: Acta Otolaryngol Subsets: MEDLINE

Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: Stockholm : Scandinavian University Press

Age of Onset* ; Gene Expression* ; Papillomavirus Infections*/genetics ; Respiratory Tract Infections*/genetics ; Social Class*; RNA, Neoplasm/*metabolism; Asian People ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Logistic Models ; Male ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction ; Recurrence ; Risk Factors

Background: Aggressive juvenile-onset recurrent respiratory papillomatosis (JORRP) threatens patient lives if not receives immediate surgical intervene. Even with surgical intervene, complete remission of this disease is not approachable. Therefore, understanding the factors relevant to disease severity and prognosis will do help to the treatment strategy and health management of this disease. Objective: This study aimed to explore the clinic, laboratory and socioeconomic characteristics of patients and evaluate the risk factors for aggressive JORRP. Methods: The information of clinical and socioeconomic status of the patients was reviewed and its association with disease severity was analyzed. Papilloma from JORRP patients undergone surgeries was used to determine HPV subtypes by real-time PCR. The profiles of mRNA expression in the papilloma were assessed using microarray. Results: Age at diagnosis and socioeconomic status were shown to associate with the severity of JORRP. There was no differential severity considering different HPV subtype. The mRNA expression of nucleotide binding oligomerization domain receptor protein 3 (NLRP3) and Gasdermin B (GSDMB) was reduced in papillomas. Conclusions: A younger age at diagnosis and low socioeconomic status were associated with the severity of JORRP. mRNA expression of NLRP3 and GSDMB in the papillomas of JORRP patients was significantly reduced. Abbreviation: JORRP: Juvenile-onset recurrent respiratory papillomatosis; RRP: Recurrent respiratory papillomatosis; OSAS: Obstructive sleep apnea syndrome; NLRP3: Nucleotide binding oligomerization domain receptor protein 3; GSDMB: Gasdermin B.

Keywords: Aggressive JORRP; HPV subtype; mRNA microarray; socioeconomic status

0 (RNA, Messenger)
0 (RNA, Neoplasm)

Recurrent respiratory papillomatosis

Date Created: 20200604 Date Completed: 20210714 Latest Revision: 20221207

20240829

10.1080/00016489.2020.1767804

32491958