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Comparison of 99m Tc-MIBI scintigraphy, ultrasound, and mammography for the diagnosis of BI-RADS 4 category lesions.
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- المؤلفون: Liu H;Liu H; Zhan H; Zhan H; Sun D; Sun D
- المصدر:
BMC cancer [BMC Cancer] 2020 May 24; Vol. 20 (1), pp. 463. Date of Electronic Publication: 2020 May 24.
- نوع النشر :
Journal Article
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
- بيانات النشر:
Original Publication: London : BioMed Central, [2001-
- الموضوع:
Breast Neoplasms/
*diagnosis ;
Carcinoma, Ductal, Breast/
*diagnosis ;
Carcinoma, Intraductal, Noninfiltrating/
*diagnosis ;
Magnetic Resonance Imaging/
*methods ;
Radionuclide Imaging/
*methods ;
Technetium Tc 99m Sestamibi/
*metabolism ;
Ultrasonography, Mammary/
*methods;
Adult ;
Aged ;
Aged, 80 and over ;
Breast Neoplasms/
diagnostic imaging ;
Breast Neoplasms/
metabolism ;
Carcinoma, Ductal, Breast/
diagnostic imaging ;
Carcinoma, Ductal, Breast/
metabolism ;
Carcinoma, Intraductal, Noninfiltrating/
diagnostic imaging ;
Carcinoma, Intraductal, Noninfiltrating/
metabolism ;
Female ;
Follow-Up Studies ;
Humans ;
Middle Aged ;
Prognosis ;
ROC Curve ;
Radiopharmaceuticals/
metabolism ;
Retrospective Studies ;
Young Adult - نبذة مختصرة :
Background: We sought to determine the diagnostic efficacy of Breast-specific gamma imaging (BSGI) in Chinese women with BI-RADS 4 category lesions and to compare this efficacy to that of ultrasound/mammography.
Methods: We retrospectively analyzed data from 177 women that had undergone BSGI of BI-RADS 4 category lesions originally detected via ultrasound and/or mammography.
Results: Of these 177 cases, 117 (66.1%) were malignant lesions and 60 (33.9%) were benign. The sensitivity, specificity, positive predictive values, and negative predictive values of BSGI were 94.9% (111/117), 78.3% (47/60), 89.5% (111/124), and 88.7% (47/53), respectively. The specificity and positive predictive values for mammography were 48.3% (29/60) and 77.5% (107/138), while for ultrasound they were 53.3% (32/60) and 79.6% (109/137), respectively. The sensitivity and specificity of BSGI for the detection of lesions ≤1 cm in size were 90.9% (10/11) and 88.0% (22/25), respectively, while for breast lesions >1 cm in size these values were 94.3% (100/106) and 71.4% (25/35), respectively. In addition, BSGI sensitivity and specificity values for dense breast tissue were 94.0% (79/84) and 78.0% (39/50), respectively, whereas for non-dense breast tissue these vales were 97.0% (32/33) and 80.0% (8/10), respectively. The sensitivity of BSGI for invasive ductal carcinomas (IDC) and ductal carcinomas in situ (DCIS) was 98.9% (95/96) and 75.0% (9/12), respectively. The tumor to normal tissue ratio of BSGI for malignant lesions was significantly higher than for benign lesions (2.18 ± 1.17 vs 1.66 ± 0.40, t = 7.56, P<0.05).
Conclusions: These results indicate that BSGI is highly sensitive for the detection of such lesions, achieving good positive/negative predictive values. This suggests that for IDC in particular, BSGI is superior to ultrasound and mammography for the diagnosis of BI-RADS 4 category lesions, although this was less apparent for the diagnosis of DCIS lesions. BSGI exhibited excellent performance in dense breast tissue and for the detection of lesions ≤1 cm in size.
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- Contributed Indexing:
Keywords: Breast cancer; Breast-specific gamma imaging/BSGI; Mammography; Ultrasound
- الرقم المعرف:
0 (Radiopharmaceuticals)
971Z4W1S09 (Technetium Tc 99m Sestamibi)
- الموضوع:
Date Created: 20200526 Date Completed: 20210202 Latest Revision: 20210202
- الموضوع:
20231215
- الرقم المعرف:
PMC7245809
- الرقم المعرف:
10.1186/s12885-020-06938-7
- الرقم المعرف:
32448217
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