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Digital Biomarkers of Mobility in Parkinson's Disease During Daily Living.

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  • معلومة اضافية
    • المصدر:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101567362 Publication Model: Print Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Amsterdam : IOS Press
    • الموضوع:
      Activities of Daily Living* ; Biomarkers* ; Monitoring, Ambulatory*/instrumentation ; Monitoring, Ambulatory*/methods ; Motor Activity*/physiology ; Outcome Assessment, Health Care*; Gait Disorders, Neurologic/*diagnosis ; Parkinson Disease/*diagnosis; Aged ; Digital Technology ; Female ; Gait Disorders, Neurologic/etiology ; Humans ; Male ; Middle Aged ; Mobility Limitation ; Parkinson Disease/complications ; Wearable Electronic Devices
    • نبذة مختصرة :
      Background: Identifying digital biomarkers of mobility is important for clinical trials in Parkinson's disease (PD).
      Objective: To determine which digital outcome measures of mobility discriminate mobility in people with PD from healthy control (HC) subjects over a week of continuous monitoring.
      Methods: We recruited 29 people with PD, and 27 age-matched HC subjects. Subjects were asked to wear three inertial sensors (Opal by APDM) attached to both feet and to the lumbar region, and a subset of subjects also wore two wrist sensors, for a week of continuous monitoring. We derived 43 digital outcome measures of mobility grouped into five domains. An Area Under Curve (AUC) was calculated for each digital outcome measures of mobility, and logistic regression employing a 'best subsets selection strategy' was used to find combinations of measures that discriminated mobility in PD from HC.
      Results: Duration of recordings was 66±14 hours in the PD and 59±16 hours in the HC. Out of a total of 43 digital outcome measures of mobility, we found six digital outcome measures of mobility with AUC > 0.80. Turn angle (AUC = 0.89, 95% CI: 0.79-0.97) and swing time variability (AUC = 0.87, 95% CI: 0.75-0.96) were the most discriminative individual measures. Turning measures were most consistently selected via the best subsets strategy to discriminate people with PD from HC, followed by gait variability measures.
      Conclusion: Clinical studies and clinical practice with digital biomarkers of daily life mobility in PD should include turning and variability measures.
    • References:
      Phys Ther. 2016 Sep;96(9):1364-71. (PMID: 27034314)
      N Engl J Med. 1988 Dec 29;319(26):1701-7. (PMID: 3205267)
      Front Neurol. 2015 Feb 26;6:34. (PMID: 25767462)
      Neurology. 2018 Oct 16;91(16):e1528-e1538. (PMID: 30232246)
      Gait Posture. 2011 May;34(1):111-8. (PMID: 21531139)
      Front Neurol. 2018 Jan 26;9:18. (PMID: 29434567)
      Sensors (Basel). 2013 Dec 27;14(1):356-69. (PMID: 24379043)
      Gait Posture. 2017 Feb;52:68-71. (PMID: 27883986)
      Mov Disord. 2019 May;34(5):657-663. (PMID: 30901495)
      J Neurol. 2001 Nov;248(11):950-8. (PMID: 11757958)
      J Neurol Neurosurg Psychiatry. 2010 Feb;81(2):171-6. (PMID: 19726406)
      Brain. 1994 Oct;117 ( Pt 5):1169-81. (PMID: 7953597)
      Arch Phys Med Rehabil. 2008 Sep;89(9):1765-71. (PMID: 18760161)
      J Neuroeng Rehabil. 2016 May 12;13(1):46. (PMID: 27175731)
      JAMA Neurol. 2018 Jul 1;75(7):876-880. (PMID: 29582075)
      Am J Phys Med Rehabil. 2008 May;87(5):354-62. (PMID: 18174852)
      Mov Disord. 2016 Sep;31(9):1293-313. (PMID: 27452964)
      Physiol Meas. 2019 Sep 30;40(9):095003. (PMID: 31470423)
      Disabil Rehabil. 2008;30(16):1222-9. (PMID: 18608364)
      J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):500-506. (PMID: 29300849)
      J Gerontol A Biol Sci Med Sci. 2016 Aug;71(8):1102-8. (PMID: 26916339)
      J Neuroeng Rehabil. 2005 Jul 20;2:19. (PMID: 16033650)
      Mov Disord. 2013 Sep 15;28(11):1544-51. (PMID: 24132842)
      Chaos. 2009 Jun;19(2):026113. (PMID: 19566273)
      Lancet Neurol. 2019 Jul;18(7):697-708. (PMID: 30975519)
      Mov Disord. 2008 Apr 30;23(6):817-23. (PMID: 18200603)
      Sci Rep. 2018 Mar 12;8(1):4316. (PMID: 29531284)
      J Neurol. 2013 Dec;260(12):2964-72. (PMID: 23900754)
      Mov Disord. 2018 Aug;33(8):1287-1297. (PMID: 29701258)
      Mov Disord. 2008 Nov 15;23(15):2129-70. (PMID: 19025984)
      Curr Opin Neurol. 2008 Aug;21(4):461-71. (PMID: 18607208)
      Gait Posture. 2012 Jul;36(3):541-5. (PMID: 22743028)
      BMC Bioinformatics. 2011 Mar 17;12:77. (PMID: 21414208)
      Mov Disord. 2013 Sep 15;28(11):1534-43. (PMID: 24132841)
      Gait Posture. 2017 Jun;55:87-93. (PMID: 28433867)
      J Bioeng Biomed Sci. 2011 Dec 12;Suppl 1:007. (PMID: 24955286)
      Mov Disord. 2008 Jul 30;23(10):1428-34. (PMID: 18543333)
      Biomed Eng Online. 2019 Jun 3;18(1):70. (PMID: 31159825)
      PLoS One. 2017 Dec 20;12(12):e0189161. (PMID: 29261709)
      Neurorehabil Neural Repair. 2013 Oct;27(8):742-52. (PMID: 23774124)
      Neurorehabil Neural Repair. 2011 Nov-Dec;25(9):810-8. (PMID: 21989633)
      J Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):820-7. (PMID: 23250001)
      NeuroRehabilitation. 2015;37(1):3-10. (PMID: 26409689)
      Nat Rev Neurol. 2018 Mar;14(3):183-189. (PMID: 29377011)
    • Grant Information:
      R43 AG044863 United States AG NIA NIH HHS; R44 AG044863 United States AG NIA NIH HHS; R44 AG055388 United States AG NIA NIH HHS
    • Contributed Indexing:
      Keywords: Parkinson’s disease; biomarkers; continuous monitoring; digital outcome measures of mobility; inertial sensors
    • الرقم المعرف:
      0 (Biomarkers)
    • الموضوع:
      Date Created: 20200518 Date Completed: 20210915 Latest Revision: 20230920
    • الموضوع:
      20240628
    • الرقم المعرف:
      PMC8128134
    • الرقم المعرف:
      10.3233/JPD-201914
    • الرقم المعرف:
      32417795