Antimicrobial ent -abietane-type diterpenoids from the roots of Euphorbia wallichii .

Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE

Publication: London : Informa Healthcare
Original Publication: [Newark, N.J.?] : Harwood Academic Publishers,

Anti-Infective Agents* ; Antineoplastic Agents, Phytogenic* ; Diterpenes*/pharmacology ; Euphorbia*; Abietanes/pharmacology ; Molecular Structure ; Plant Roots

Three previously undescribed ent -abietane-type diterpenoids, designated as 11 β -hydroxy-14-oxo-17-al- ent -abieta-8(9),13(15)-dien-16,12 β -olide ( 1 ), 11 β ,17-dihydroxy-12-methoxy- ent -abieta-8(14),13(15)-dien-16,12 ɑ -olide ( 2 ), and 14 ɑ -hydroxy-17-al- ent -abieta-7(8),11(12),13(15)-trien-16,12-olide ( 3 ), were isolated from 95% ethanol extract of the roots of Euphorbia wallichii . The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated diterpenoids were tested in vitro for antimicrobial potentials against 6 pathogenic microorganisms. As a result, compounds 1 - 3 exhibited some antimicrobial activity against the tested Gram positive bacteria with minimum inhibitory concentration values less than 60 μg/ml.[Formula: see text].

Keywords: Euphorbia wallichii; Euphorbiaceae; antimicrobial activity; ent-abietane-type diterpenoids

0 (Abietanes)
0 (Anti-Infective Agents)
0 (Antineoplastic Agents, Phytogenic)
0 (Diterpenes)

Date Created: 20200515 Date Completed: 20210630 Latest Revision: 20210630

20240628

10.1080/10286020.2020.1758931

32406751