Influence of Polymer Composition on the Controlled Release of Docetaxel: A Comparison of Non-Degradable Polymer Films for Oesophageal Drug-Eluting Stents.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE

Original Publication: Basel, Switzerland : MDPI

Following the huge clinical success of drug-eluting vascular stents, there is a significant interest in the development of drug-eluting stents for other applications, such as the treatment of gastrointestinal (GI) cancers. Central to this process is understanding how particular drugs are released from stent coatings, which to a large extent is controlled by drug-polymer interactions. Therefore, in this study we investigated the release of docetaxel (DTX) from a selection of non-degradable polymer films. DTX-polymer films were prepared at various loadings (1, 5 and 10% w / w ) using three commercially available polymers including poly(dimethylsiloxane) (PSi), poly (ethylene- co -vinyl acetate) (PEVA) and Chronosil polyurethane (PU). The formulations were characterised using different techniques such as photoacoustic Fourier-transform infrared (PA-FTIR) spectrophotometry, X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The effect of DTX on the mechanical properties of the films, in-vitro release, and degradation tests were also assessed. For all polymers and DTX loadings, the drug was found to disperse homogenously without crystallisation within the polymer matrix. While no specific interactions were observed between DTX and PSi or PEVA, hydrogen-bonding appeared to be present between DTX and PU, which resulted in a concentration-dependent decrease in the Young's moduli of the films due to disruption of inter-polymeric molecular interactions. In addition, the DTX-PU interactions were found to modulate drug release, providing near-linear release over 30 days, which was accompanied by a significant reduction in degradation products. The results indicate that DTX-loaded PU films are excellent candidates for drug-eluting stents for the treatment of oesophageal cancer.

J Control Release. 2008 Dec 18;132(3):153-63. (PMID: 18817820)
Eur J Pharm Sci. 2016 Jul 30;90:53-63. (PMID: 26545484)
J Control Release. 2011 Oct 30;155(2):262-71. (PMID: 21704664)
J Control Release. 2017 Sep 28;262:284-295. (PMID: 28789964)
Int J Pharm. 2012 May 10;427(2):276-83. (PMID: 22366483)
Gastrointest Endosc. 2005 Feb;61(2):296-301. (PMID: 15729251)
Gastrointest Endosc. 1993 Sep-Oct;39(5):670-3. (PMID: 8224690)
Eur J Pharm Biopharm. 2015 Feb;90:44-52. (PMID: 25448075)
J Control Release. 2008 May 22;128(1):23-31. (PMID: 18374444)
J Control Release. 2019 Aug 28;308:209-231. (PMID: 31279817)
Gastrointest Endosc. 2007 Oct;66(4):798-803. (PMID: 17905025)
Am J Gastroenterol. 2010 Feb;105(2):258-73; quiz 274. (PMID: 20029413)
Am J Cardiol. 2007 Oct 22;100(8B):3M-9M. (PMID: 17950830)
Drug Test Anal. 2014 Oct;6(10):1076-84. (PMID: 24574150)
Biomed Mater. 2011 Oct;6(5):055003. (PMID: 21849722)
Contraception. 2003 Mar;67(3):187-94. (PMID: 12618252)
J Pharm Biomed Anal. 2007 Mar 12;43(4):1228-35. (PMID: 17126518)
J Control Release. 2013 Nov 28;172(1):105-117. (PMID: 23958902)
Int J Nanomedicine. 2017 Oct 17;12:7669-7680. (PMID: 29089762)
Expert Opin Drug Deliv. 2010 Apr;7(4):429-44. (PMID: 20331353)
J Biomater Appl. 2015 Mar;29(8):1133-44. (PMID: 25252589)
J Support Oncol. 2006 Sep;4(8):365-73, 379. (PMID: 17004508)
JAMA. 1960 Dec 17;174:2052-4. (PMID: 13741481)
World J Gastroenterol. 2016 Jan 14;22(2):842-52. (PMID: 26811630)
Int J Mol Sci. 2012;13(4):4906-19. (PMID: 22606019)
Dig Dis Sci. 2013 Mar;58(3):865-71. (PMID: 23179148)
Biofouling. 2010 Nov;26(8):961-72. (PMID: 21058057)
Gan To Kagaku Ryoho. 2006 Mar;33(3):337-43. (PMID: 16531714)
Mol Pharm. 2015 Jul 6;12(7):2305-17. (PMID: 25936529)
Ann Pharmacother. 2001 Mar;35(3):329-36. (PMID: 11261531)
Biomed Microdevices. 2014 Dec;16(6):897-904. (PMID: 25135441)
Biomater Res. 2014 Oct 08;18:15. (PMID: 26331066)
Gastrointest Endosc. 2009 Oct;70(4):614-9. (PMID: 19539918)
Mov Disord. 2007 Dec;22(16):2398-404. (PMID: 17935234)
J Clin Oncol. 2000 May;18(10):2095-103. (PMID: 10811675)
Plast Reconstr Surg. 1994 May;93(6):1123-31; discussion 1132-3. (PMID: 8171130)
Sci Technol Adv Mater. 2012 Apr 3;13(2):025005. (PMID: 27877483)
Drug Dev Ind Pharm. 2008 Jun;34(6):588-94. (PMID: 18568908)
Invest New Drugs. 2002 Feb;20(1):95-9. (PMID: 12003198)
Sci Technol Adv Mater. 2013 Sep 27;14(5):055006. (PMID: 27877613)
Int J Pharm. 2010 Nov 15;400(1-2):66-73. (PMID: 20804834)
J Control Release. 2012 Apr 10;159(1):14-26. (PMID: 22154931)
Clin Endosc. 2013 Jul;46(4):355-67. (PMID: 23964332)
Gastrointest Endosc. 2011 Apr;73(4):727-33. (PMID: 21288514)
Nanomaterials (Basel). 2019 Aug 20;9(8):. (PMID: 31434204)
J Pharm Sci. 2008 Oct;97(10):4228-39. (PMID: 18338805)
JAMA Oncol. 2017 Apr 1;3(4):524-548. (PMID: 27918777)
Gastrointest Cancer Res. 2008 Mar;2(2):85-92. (PMID: 19259300)
Dent Mater. 2007 Apr;23(4):404-9. (PMID: 16556460)
J Control Release. 2007 Apr 23;118(3):318-24. (PMID: 17289208)
Pharmaceutics. 2018 May 09;10(2):. (PMID: 29747409)
Gastrointest Endosc. 2009 May;69(6):1140-7. (PMID: 19243763)
J Pharm Pharmacol. 2007 May;59(5):661-7. (PMID: 17524231)
J Control Release. 2010 Aug 17;146(1):45-53. (PMID: 20566400)
Org Biomol Chem. 2009 Sep 7;7(17):3437-46. (PMID: 19675898)
J Control Release. 2009 Aug 4;137(3):224-33. (PMID: 19376173)
Dis Esophagus. 2009;22(4):331-6. (PMID: 19473211)
Oncol Lett. 2013 Sep;6(3):713-718. (PMID: 24137396)
Int J Pharm. 2013 Jun 25;450(1-2):145-62. (PMID: 23632262)
Int J Pharm. 2012 May 10;427(2):242-51. (PMID: 22349052)
Eur J Pharm Biopharm. 2008 Jun;69(2):527-34. (PMID: 18359617)

Keywords: controlled release; docetaxel; non-degradable polymer; oesophageal drug-eluting stent

Date Created: 20200515 Latest Revision: 20200928

20240628

PMC7284596

10.3390/pharmaceutics12050444

32403329