Fifty Years of Influenza A(H3N2) Following the Pandemic of 1968.

Publisher: American Public Health Association Country of Publication: United States NLM ID: 1254074 Publication Model: Print Cited Medium: Internet ISSN: 1541-0048 (Electronic) Linking ISSN: 00900036 NLM ISO Abbreviation: Am J Public Health Subsets: MEDLINE

Publication: Washington, DC : American Public Health Association
Original Publication: New York [etc.]

Influenza A Virus, H3N2 Subtype* ; Pandemics*; Influenza, Human/*epidemiology; Age Factors ; Antiviral Agents/therapeutic use ; Hospitalization/statistics & numerical data ; Humans ; Influenza Vaccines/administration & dosage ; Influenza, Human/drug therapy ; Influenza, Human/prevention & control ; Severity of Illness Index ; Spatio-Temporal Analysis ; United States/epidemiology

In 2018, the world commemorated the centennial of the 1918 influenza A(H1N1) pandemic, the deadliest pandemic in recorded history; however, little mention was made of the 50th anniversary of the 1968 A(H3N2) pandemic. Although pandemic morbidity and mortality were much lower in 1968 than in 1918, influenza A(H3N2) virus infections have become the leading cause of seasonal influenza illness and death over the last 50 years, with more than twice the number of hospitalizations from A(H3N2) as from A(H1N1) during the past six seasons. We review the emergence, progression, clinical course, etiology, epidemiology, and treatment of the 1968 pandemic and highlight the short- and long-term impact associated with A(H3N2) viruses. The 1968 H3N2 pandemic and its ongoing sequelae underscore the need for improved seasonal and pandemic influenza prevention, control, preparedness, and response efforts.

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0 (Antiviral Agents)
0 (Influenza Vaccines)

Date Created: 20200409 Date Completed: 20200630 Latest Revision: 20231113

20231113

PMC7144439

10.2105/AJPH.2019.305557

32267748