Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Genetic Association Studies* ; Molecular Targeted Therapy*; Chemokine CXCL12/*genetics ; Chemokine CXCL12/*metabolism ; Lichen Planus, Oral/*drug therapy ; Lichen Planus, Oral/*genetics ; Mouth Mucosa/*metabolism ; Receptors, CXCR4/*genetics ; Receptors, CXCR4/*metabolism; Benzylamines ; Computational Biology ; Cyclams ; Female ; Heterocyclic Compounds/therapeutic use ; Humans ; Male ; Up-Regulation

Today, we face difficulty in generating new hypotheses and understanding oral lichen planus due to the large amount of biomedical information available. In this research, we have used an integrated bioinformatics approach assimilating information from data mining, gene ontologies, protein-protein interaction and network analysis to predict candidate genes related to oral lichen planus. A detailed pathway analysis led us to propose two promising therapeutic targets: the stromal cell derived factor 1 (CXCL12) and the C-X-C type 4 chemokine receptor (CXCR4). We further validated our predictions and found that CXCR4 was upregulated in all oral lichen planus tissue samples. Our bioinformatics data cumulatively support the pathological role of chemokines and chemokine receptors in oral lichen planus. From a clinical perspective, we suggest a drug (plerixafor) and two therapeutic targets for future research.

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0 (Benzylamines)
0 (CXCL12 protein, human)
0 (CXCR4 protein, human)
0 (Chemokine CXCL12)
0 (Cyclams)
0 (Heterocyclic Compounds)
0 (Receptors, CXCR4)
S915P5499N (plerixafor)

Date Created: 20200328 Date Completed: 20201216 Latest Revision: 20211204

20250114

PMC7096434

10.1038/s41598-020-62258-7

32214134