Stepwise progressive parametric multiple testing procedure with correlated normal test statistics.

Publisher: Taylor & Francis Country of Publication: England NLM ID: 9200436 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5711 (Electronic) Linking ISSN: 10543406 NLM ISO Abbreviation: J Biopharm Stat Subsets: MEDLINE

Publication: 2005- : Abingdon, Oxford : Taylor & Francis
Original Publication: New York, N.Y. : Marcel Dekker, c1991-

Data Interpretation, Statistical*; Clinical Trials as Topic/*statistics & numerical data ; Computer Simulation/*statistics & numerical data ; Research Design/*statistics & numerical data; Central Nervous System Stimulants/therapeutic use ; Humans ; Modafinil/therapeutic use ; Multivariate Analysis

Multiple testing problems are often seen in clinical trials. An appropriate testing procedure should be specified to deal with the potential inflation of type I error rate due to multiplicity. In this article, we propose a stepwise progressive parametric multiple (SPPM) testing procedure, which constructs the testing using the products of all the combinations of local [Formula: see text]-values and the critical values are determined by numerical integrations progressively using the closure principle. We have compared the performance of SPPM to several other procedures, and demonstrate the advantage of SPPM procedure, in terms of power, for the certain situations of multiple testing.

Keywords: Group sequential design; multiple primary endpoints; multivariate Normal distribution; stopping boundaries

0 (Central Nervous System Stimulants)
R3UK8X3U3D (Modafinil)

Date Created: 20200320 Date Completed: 20210708 Latest Revision: 20210708

20231215

10.1080/10543406.2020.1726369

32191556