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Association between plasma dipeptidyl peptidase-4 activity to brain-derived neurotrophic factor ratio and depressive symptoms in middle-aged and older adults with normal glucose tolerance: A cross-sectional study.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Glasgow : WFSBP, 2000-
    • الموضوع:
      Brain-Derived Neurotrophic Factor/*blood ; Depression/*blood ; Depression/*psychology ; Dipeptidyl Peptidase 4/*blood ; Glucose/*metabolism; Aged ; Cross-Sectional Studies ; F2-Isoprostanes/blood ; Humans ; Inflammation/blood ; Middle Aged ; Oxidative Stress ; Tyrosine/analogs & derivatives ; Tyrosine/blood
    • نبذة مختصرة :
      Objectives: Attenuation of brain-derived neurotrophic factor (BDNF) availability and increased dipeptidyl peptidase-4 (DPP4) activity have both been reported to link to the pathogenesis of depression. The aim of this study was to test the correlation between depressive symptoms and plasma DPP4 activity to BDNF ratio (DBR). Methods: We evaluated DPP4 activity, BDNF, oxidative stress parameters and inflammatory markers and calculated DBR in a cross-sectional sample of 1640 non-diabetic participants. Results: DPP4 activity was negatively related to BDNF in participants with and without depressive symptoms ( r = -0.351 and r = -0.404, p <.001). Nitrotyrosine and 8-iso-PGF2a mediated 18.4 and 12.6% of the total effect of DPP4 activity on BDNF, respectively. 8-iso-PGF2a, nitrotyrosine, C-reactive protein, interleukin-6 and PHQ-9 score progressively increased across DBR quartiles. Participants whose DBRs were in the highest quartile had 2.64-fold increased odds (OR = 3.03) of depressive symptoms. The depressive symptoms risk increased more with lower levels of BDNF and higher levels of DPP4 activity ( p <.05). Conclusions: Our data suggested inverse correlation between DPP4 activity and BDNF through the oxidative stress mediator. The positive relationship between DBR and depressive symptoms risk raises feasibility of identifying DBR as a novel biological marker or even a possible therapeutic target for depression.
    • Contributed Indexing:
      Keywords: DPP4 activity to BDNF ratio; depressive symptoms; inflammation; normal glucose tolerance; oxidative stress
    • الرقم المعرف:
      0 (Brain-Derived Neurotrophic Factor)
      0 (F2-Isoprostanes)
      3604-79-3 (3-nitrotyrosine)
      42HK56048U (Tyrosine)
      EC 3.4.14.5 (Dipeptidyl Peptidase 4)
      IY9XDZ35W2 (Glucose)
    • الموضوع:
      Date Created: 20200222 Date Completed: 20210329 Latest Revision: 20210329
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1080/15622975.2020.1733078
    • الرقم المعرف:
      32081046