Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Stability of Arsenic Species During Bioaccessibility Assessment Using the In Vitro UBM and HPLC-ICP-MS Detection.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London, Clifton, N. J.] Humana Press.
    • الموضوع:
      Arsenic*/analysis ; Arsenicals*; Chromatography, High Pressure Liquid ; Europe ; Mass Spectrometry ; Reproducibility of Results
    • نبذة مختصرة :
      The stability of four major arsenic (As) species during application of the BARGE (Bioaccessibility Research Group of Europe) unified bioaccessibility method (UBM) has been assessed. The concentrations of As species in the UBM gastric and gastro-intestinal (gastric + intestinal) phases were determined using HPLC-ICP-MS whilst the total As content in the samples was determined using ICP-MS alone. The arsenic species studied were arsenite As(III), arsenate As(V), dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA). These species were separated in 10 min using an anion exchange column (Hamilton PRP-X100) with a mobile phase containing 20 mmol L -1 NH 4 H 2 PO 4 /1% methanol (pH 6.0). The recoveries of arsenic species spiked into the gastric and gastro-intestinal fluids were in the range 90-108%. No interconversion between As species was observed as a result of applying the BARGE UBM, which is a particularly important finding for the reliability of As(III) measurements. The accuracy of the BARGE UBM for in vitro extractable As(V) was verified using British Geological Survey (BGS) guidance material 102 (an ironstone soil). For a commercial rice sample, the bioaccessibility sequence of As was DMA > As(III) > As(V) for the gastric phase and As(III) > DMA > As(V) for the gastro-intestinal phase.
    • Grant Information:
      FBA-2015-5939 Erciyes Üniversitesi
    • Contributed Indexing:
      Keywords: Arsenic speciation; Bioaccessibility; HPLC-ICP-MS; Stability; Unified bioaccessibility method (UBM)
    • الرقم المعرف:
      0 (Arsenicals)
      N712M78A8G (Arsenic)
    • الموضوع:
      Date Created: 20200221 Date Completed: 20210618 Latest Revision: 20210618
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1007/s12011-020-02066-2
    • الرقم المعرف:
      32076953