Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.

Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0370364 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0447 (Electronic) Linking ISSN: 0001690X NLM ISO Abbreviation: Acta Psychiatr Scand Subsets: MEDLINE

Publication: Malden, MA : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard International Publishers

Emotional Regulation*; Adverse Childhood Experiences/*psychology ; Multifactorial Inheritance/*genetics ; Psychotic Disorders/*genetics ; Schizophrenia/*genetics; Adolescent ; Affect ; Child ; Ecological Momentary Assessment ; Female ; Gene-Environment Interaction ; Humans ; Male ; Risk Factors ; Stress, Psychological/genetics ; Twins ; Young Adult

Objective: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.
Methods: The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models.
Results: Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures.
Conclusion: Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.
(© 2020 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.)

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Keywords: childhood trauma; daily-life stressors; emotion regulation; experience sampling method; gene-environment interaction; psychosis

Date Created: 20200207 Date Completed: 20210510 Latest Revision: 20210510

20240628

PMC7318228

10.1111/acps.13158

32027017