Cerebrospinal fluid influx drives acute ischemic tissue swelling.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Brain Edema/*cerebrospinal fluid ; Brain Edema/*etiology ; Glymphatic System/*physiopathology ; Stroke/*cerebrospinal fluid ; Stroke/*complications; Animals ; Aquaporin 5/metabolism ; Brain Edema/diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Inbred C57BL ; Stroke/diagnostic imaging ; Vasoconstriction

Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies.
(Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

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K08 NS089830 United States NS NINDS NIH HHS; R35 NS097265 United States NS NINDS NIH HHS; RF1 AG053991 United States AG NIA NIH HHS; RF1 NS110049 United States NS NINDS NIH HHS; R01 NS100366 United States NS NINDS NIH HHS; RF1 AG057575 United States AG NIA NIH HHS

0 (Aquaporin 5)

Date Created: 20200201 Date Completed: 20200409 Latest Revision: 20210313

20240829

PMC7375109

10.1126/science.aax7171

32001524