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Associations between high blood pressure and DNA methylation.

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  • معلومة اضافية
    • المصدر:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: San Francisco, CA : Public Library of Science
    • الموضوع:
      DNA Methylation*; Blood Pressure/*genetics ; CpG Islands/*genetics ; Epigenome/*genetics ; Hypertension/*genetics; Adult ; Asian People/genetics ; Cohort Studies ; Emigrants and Immigrants ; Epigenesis, Genetic ; Genome-Wide Association Study ; Humans ; Hypertension/epidemiology ; Male ; Middle Aged ; Risk Factors ; United Kingdom/epidemiology ; White People/genetics
    • نبذة مختصرة :
      Background: High blood pressure is a major risk factor for cardiovascular disease and is influenced by both environmental and genetic factors. Epigenetic processes including DNA methylation potentially mediate the relationship between genetic factors, the environment and cardiovascular disease. Despite an increased risk of hypertension and cardiovascular disease in individuals of South Asians compared to Europeans, it is not clear whether associations between blood pressure and DNA methylation differ between these groups.
      Methods: We performed an epigenome-wide association study and differentially methylated region (DMR) analysis to identify DNA methylation sites and regions that were associated with systolic blood pressure, diastolic blood pressure and hypertension. We analyzed samples from 364 European and 348 South Asian men (first generation migrants to the UK) from the Southall And Brent REvisited cohort, measuring DNA methylation from blood using the Illumina Infinium® HumanMethylation450 BeadChip.
      Results: One CpG site was found to be associated with DBP in trans-ancestry analyses (i.e. both ethnic groups combined), while in Europeans alone seven CpG sites were associated with DBP. No associations were identified between DNA methylation and either SBP or hypertension. Comparison of effect sizes between South Asian and European EWAS for DBP, SBP and hypertension revealed little concordance between analyses. DMR analysis identified several regions with known relationships with CVD and its risk factors.
      Conclusion: This study identified differentially methylated sites and regions associated with blood pressure and revealed ethnic differences in these associations. These findings may point to molecular pathways which may explain the elevated cardiovascular disease risk experienced by those of South Asian ancestry when compared to Europeans.
      Competing Interests: TRG receives funding from GlaxoSmithKline, Biogen and Sanofi for research unrelated to the work presented here. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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    • Grant Information:
      United Kingdom DH_ Department of Health; MC_UU_12013/8 United Kingdom MRC_ Medical Research Council; 082464/Z/07/C United Kingdom WT_ Wellcome Trust; United Kingdom Wellcome Trust; CS/13/1/30327 United Kingdom BHF_ British Heart Foundation; MC_UU_12019/1 United Kingdom MRC_ Medical Research Council; MC_UU_00011/4 United Kingdom MRC_ Medical Research Council; MC_UU_12013/2 United Kingdom MRC_ Medical Research Council; MC_UU_00019/2 United Kingdom MRC_ Medical Research Council; MC_UU_00011/5 United Kingdom MRC_ Medical Research Council
    • الموضوع:
      Date Created: 20200131 Date Completed: 20200416 Latest Revision: 20221207
    • الموضوع:
      20240628
    • الرقم المعرف:
      PMC6991984
    • الرقم المعرف:
      10.1371/journal.pone.0227728
    • الرقم المعرف:
      31999706