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Viral Tropism in Human Immunodeficiency Virus Type 1-Infected Children and Adolescents in Thailand.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 101586049 Publication Model: Print Cited Medium: Internet ISSN: 2048-7207 (Electronic) Linking ISSN: 20487193 NLM ISO Abbreviation: J Pediatric Infect Dis Soc Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford : Oxford University Press
    • الموضوع:
      Viral Tropism*/genetics; HIV Infections/*virology ; HIV-1/*physiology; Adolescent ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Genotyping Techniques ; HIV Envelope Protein gp120/genetics ; HIV Infections/epidemiology ; HIV-1/genetics ; Humans ; Male ; Peptide Fragments/genetics ; Thailand/epidemiology ; Viral Load
    • نبذة مختصرة :
      Background: Maraviroc, a C-C chemokine receptor 5 (CCR5) antagonist, has been used as an alternative antiretroviral drug in treatment-experienced adults and children infected by CCR5-tropic human immunodeficiency virus type 1 (HIV-1) isolates. Prior to widespread use of this drug, rates of HIV-1 coreceptor tropism and factors associated with coreceptor tropism had to be determined.
      Methods: HIV-1-infected individuals aged <20 years with HIV-1 viral loads >1000 RNA copies/mL who were treatment-experienced or treatment-naive were enrolled. HIV-1 coreceptor tropism was determined using a genotypic test in which V3 sequences were analyzed with GENO2PHENO version 2.5 and a false discovery rate of 5%.
      Results: Fifty-two HIV-1-infected patients were recruited. The median age of participants was 14.9 years (interquartile range [IQR], 8.9-16.8 years). The median CD4 cell count was 396.0 cells/µL (IQR, 72.0-630.3 cells/µL). The median HIV-1 viral load was 43 339 RNA copies/mL (IQR, 8874-197 055 copies/mL). Thirty-nine patients (75%) were treatment-experienced. The most prevalent HIV-1 subtype in this population was CRF01_AE (36 patients, 69.2%). Based on analyses of V3 loop sequences, 5 of 13 treatment-naive patients (38.5%) and 11 of 39 treatment-experienced patients (28.2%) were infected by R5 viruses, while 7 of 13 treatment-naive patients (53.8%) and 19 of 39 treatment-experienced patients (48.7%) were infected by X4 viruses. The only factor associated with the presence of X4 viruses was HIV-1 subtype CRF01_AE.
      Conclusions: X4-tropic viruses are associated with the CRF01_AE subtype. Hence, testing of HIV tropism should be performed before treatment with CCR5 inhibitors in children in areas where CRF01_AE predominates.
      (© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
    • Contributed Indexing:
      Keywords: GENO2PHENO genotypic test; HIV coreceptor tropism; pediatric HIV infection
    • الرقم المعرف:
      0 (HIV Envelope Protein gp120)
      0 (HIV envelope protein gp120 (305-321))
      0 (Peptide Fragments)
    • الموضوع:
      Date Created: 20200126 Date Completed: 20210225 Latest Revision: 20210225
    • الموضوع:
      20240829
    • الرقم المعرف:
      10.1093/jpids/piaa004
    • الرقم المعرف:
      31981458