Nanosized hydroxyapatite and β-tricalcium phosphate composite: Physico-chemical, cytotoxicity, morphological properties and in vivo trial.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Bone Regeneration*; Biocompatible Materials/*chemistry ; Calcium Phosphates/*chemistry ; Durapatite/*chemistry ; Nanoparticles/*chemistry; Animals ; Bone Substitutes ; Bone and Bones ; Microscopy, Electron, Scanning ; Orthopedics ; Porosity ; Postoperative Period ; Rats ; Rats, Wistar ; X-Ray Diffraction

The objective of this work was to characterize the properties of a synthetic biomaterial composite with nanoparticles size (Blue Bone). This biomaterial is a composite recommended for dental and orthopedic grafting surgery, for guided bone regeneration, including maxillary sinus lift, fresh alveolus filling, and treatment of furcation lesions. The nano biomaterials surface area is from 30% to 50% higher than those with micro dimensions. Another advantage is that the alloplastic biomaterial has homogeneous properties due to the complete manufacturing control. The analyzed biomaterial composite was characterized by XRD, cytochemistry, scanning electron microscopy, porosimetry and in vivo experiments (animals). The results showed that the analyzed biomaterial composite has 78.76% hydroxyapatite [Ca 5 (PO 4 ) 3 (OH)] with monoclinic structure, 21.03% β-tricalcium phosphate [β -Ca 3 (PO 4 ) 2 ] with trigonal structure and 0.19% of CaO with cubic structure, nanoparticles with homogeneous shapes, and nanoporosity. The in vivo experiments showed that the composite has null cytotoxicity, and the site of insertion biomaterials has a high level of vascularization and bone formation. The conclusion is that the synthetic biomaterial with Blue Bone designation presents characteristics suitable for use in grafting surgery applications.

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0 (Biocompatible Materials)
0 (Bone Substitutes)
0 (Calcium Phosphates)
0 (beta-tricalcium phosphate)
91D9GV0Z28 (Durapatite)

Date Created: 20191222 Date Completed: 20201204 Latest Revision: 20210110

20240829

PMC6925105

10.1038/s41598-019-56124-4

31863078