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Ethics of alternative trial designs and methods in low-resource settings.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BioMed Central, 2006-
    • الموضوع:
      Health Resources*; Research Design/*legislation & jurisprudence ; Therapeutic Human Experimentation/*ethics; Healthy Volunteers ; Humans ; Therapeutic Human Experimentation/economics ; Therapeutic Human Experimentation/legislation & jurisprudence
    • نبذة مختصرة :
      This editorial introduces articles in this Special Issue, which are based on presentations given at the 2017 meeting of the Global Forum of Bioethics in Research meeting. The main themes presented at the meeting were the use of cluster randomized trials, stepped-wedge cluster randomized trials, and controlled human infection models in research conducted in low-resource settings. The editorial sets out which ethical issues may arise in the context of alternative trial designs and describes the articles in this issue that addresses some or more of the ethical issues, such as justification of the research design, risk-benefit evaluations and consent.
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    • Grant Information:
      United Kingdom WT_ Wellcome Trust
    • Contributed Indexing:
      Keywords: Adaptive trials; Alternative trial designs; Cluster randomized trials; Controlled human challenge studies; Ethics; Stepped wedge cluster randomized trials
    • الموضوع:
      Date Created: 20191220 Date Completed: 20200917 Latest Revision: 20231027
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC6921382
    • الرقم المعرف:
      10.1186/s13063-019-3841-2
    • الرقم المعرف:
      31852513