Association between daptomycin susceptibility and teicoplanin resistance in Staphylococcus epidermidis.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Drug Resistance, Bacterial*; Anti-Bacterial Agents/*pharmacology ; Daptomycin/*pharmacology ; Staphylococcal Infections/*drug therapy ; Staphylococcus epidermidis/*drug effects ; Teicoplanin/*pharmacology; Aged ; Anti-Bacterial Agents/therapeutic use ; Catheter-Related Infections/drug therapy ; Catheter-Related Infections/microbiology ; Daptomycin/therapeutic use ; Dose-Response Relationship, Drug ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Staphylococcal Infections/microbiology ; Staphylococcus epidermidis/isolation & purification ; Surgical Wound Infection/drug therapy ; Surgical Wound Infection/microbiology ; Teicoplanin/therapeutic use ; Treatment Failure

Staphylococcus epidermidis infections are a common occurrence in hospitals, particularly in catheter-related bloodstream and surgical site infections and infective endocarditis. Higher daptomycin minimum inhibitory concentration (MIC) values may be associated with daptomycin treatment failure among patients with S. epidermidis infections. We therefore conducted a retrospective cohort study to determine the predictive value of daptomycin susceptibility. A retrospective study was undertaken in 1,337 patients with S. epidermidis infections. Data were collected from 1 January 2013 to 31 December 2016 at Ehime University Hospital, and included the following clinicopathological factors for evaluation: age, sex, resistance to vancomycin or teicoplanin, and history of antimicrobial therapy. Multiple analysis was performed using logistic regression to identify factors that independently and significantly affected the daptomycin resistance. Daptomycin-resistant S. epidermidis was identified in 38 (2.8%) patients. According to the multiple analysis, only higher MIC values (≥16 mg/L) for teicoplanin (P < 0.0001) were independently associated with an increased risk of developing daptomycin resistance. In conclusion, higher teicoplanin MIC values may predict resistance to daptomycin treatment in S. epidermidis infections.

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0 (Anti-Bacterial Agents)
61036-62-2 (Teicoplanin)
NWQ5N31VKK (Daptomycin)

Date Created: 20191208 Date Completed: 20201111 Latest Revision: 20210110

20250114

PMC6898446

10.1038/s41598-019-55149-z

31811214