Occupational exposure to organic dusts and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study.

Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: eCollection Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open

Original Publication: London : BMJ Publishing Group, [2015]-

Arthritis, Rheumatoid/*epidemiology ; Dust/*immunology ; Occupational Diseases/*epidemiology ; Occupational Exposure/*adverse effects; Animals ; Animals, Domestic/immunology ; Animals, Laboratory/immunology ; Arthritis, Rheumatoid/immunology ; Case-Control Studies ; Female ; Flour/adverse effects ; Humans ; Logistic Models ; Male ; Middle Aged ; Occupational Diseases/immunology ; Risk Factors ; Sweden/epidemiology ; Textiles/adverse effects ; Wood/adverse effects

Objectives: We estimated the association between occupational exposures to five different organic dusts: wood, animal, paper, textile and flour dust and the risk of developing rheumatoid arthritis (RA).
Methods: This population-based case-control study analysed 12 582 incident cases and 129 335 controls. Participants were identified from national public authority and quality registers. Census data on occupations were collected 1960-2010 and we estimated the exposure to organic dust with the help of job-exposure matrices. We used logistic regression to assess the OR of seropositive or seronegative RA. Estimates were adjusted for the matching variables (sex, county, age and index year), education and occupational silica exposure.
Results: Exposure to animal dust was associated with an increased risk of RA among both men and women. The OR was 1.2 (95% CI=1.1 to 1.4) for seropositive RA and 1.3 (95% CI=1.1 to 1.5) for seronegative RA among ever exposed participants compared with unexposed. The risk increased with duration of exposure for seropositive RA, and participants who had been exposed in five or more censuses had an OR of 1.6 (95% CI=1.1 to 2.2, p for trend=0.003). Exposure to textile dust also generated a significant dose-response relationship for seropositive RA (p for trend=0.014). We detected no association between exposure to wood, paper or flour dust and risk of RA.
Conclusions: Overall, exposure to animal dust and textile dust was associated with an increased risk of developing RA. These observations give further support to the notion that airborne exposures are involved in the aetiology of RA.
Competing Interests: Competing interests: LA have for the EIRA study been supported by research grants from the Swedish Medical Research Council; the Swedish Council for Health, Working Life and Welfare; King Gustaf V:s 80-year foundation; the Swedish Rheumatism Foundation; Stockholm County Council; the insurance company AFA Insurance and the IMI-supported RTCure projects, unrelated to the submitted work. PW has received research grants from AFA Insurance, unrelated to the submitted work. PG has received research grants from the Swedish Research Council for Health, Working Life and Welfare, unrelated to the submitted work. LA received grants from the Swedish Research Council for Health, Working Life and Welfare (grant no: 2013-0194) and AFA Insurance (grant number 120299) to support the present study.
(© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

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Keywords: epidemiology; rheumatoid arthritis; smoking

0 (Dust)

Date Created: 20191206 Date Completed: 20200629 Latest Revision: 20200629

20240829

PMC6890392

10.1136/rmdopen-2019-001049

31803499