Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women.

Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

Original Publication: [Malden, MA] : John Wiley & Sons Ltd., c2012-

Abortion, Induced/*statistics & numerical data ; Breast Density/*physiology ; Breast Neoplasms/*epidemiology ; Postmenopause/*physiology; Adult ; Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Breast Neoplasms/physiopathology ; Case-Control Studies ; China/epidemiology ; Female ; Humans ; Incidence ; Middle Aged ; Odds Ratio ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Risk Factors

The incidence of breast cancer has increased dramatically in China. We evaluated the clinical and epidemiologic factors associated with breast cancer, and its stage in a case-control study of Northeast Chinese women. We also examined whether these factors were differentially distributed among molecular subtypes of breast cancer in a case-only analysis. We identified 1118 breast cancer patients and 2284 healthy women from Cancer Hospital of Medical University between January 2014 and December 2017. Logistic regression models were used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). We found that postmenopausal women had a decreased risk of breast cancer (multivariate-adjusted OR = 0.33, 95% CI:0.25-0.43), and tended to have breast cancer of human epidermal growth factor receptor 2 (HER2)-overexpressing (multivariate-adjusted OR = 2.99, 95% CI: 1.49-5.97) and triple-negative (multivariate-adjusted OR = 2.16, 95% CI: 1.02-4.56) subtypes, compared with the luminal B subtype. Women with history of abortion had an increased risk of breast cancer (multivariate-adjusted OR = 4.70, 95% CI: 3.60-6.14). Women with high breast density and high Breast Imaging Reporting and Data System (BIRADS) scores of lesions tended to have breast cancer of advanced stage, but were not differentially distributed among its molecular subtypes. In conclusion, postmenopausal women had decreased risk of breast cancer, and tended to have nonluminal subtype, while women with history of abortion had increased risk of breast cancer. Women with high breast density and BIRADS scores of lesions tended to have advanced stage breast cancer. We provide evidence on the epidemiologic factors for breast cancer and its subtypes, which may help with breast cancer risk stratification.
(© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)

Environ Health Perspect. 1983 Mar;49:185-99. (PMID: 6403347)
J Epidemiol. 2014;24(1):67-76. (PMID: 24270059)
J Natl Cancer Inst. 2009 May 20;101(10):736-50. (PMID: 19436038)
Lancet Oncol. 2012 Nov;13(11):1141-51. (PMID: 23084519)
J Natl Cancer Inst. 2014 May 10;106(5):. (PMID: 24816206)
Cancer Med. 2019 Apr;8(4):1882-1892. (PMID: 30761775)
Arch Iran Med. 2016 Oct;19(10):680-686. (PMID: 27743431)
J Natl Cancer Inst. 2015 Apr 13;107(7):. (PMID: 25868578)
Cancer Med. 2019 Dec;8(17):7431-7445. (PMID: 31642614)
J Clin Oncol. 2003 Feb 1;21(3):467-72. (PMID: 12560437)
J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):3-15. (PMID: 12160084)
Int J Cancer. 2012 Dec 1;131(11):2622-31. (PMID: 22377956)
Cancer Causes Control. 2014 Feb;25(2):227-36. (PMID: 24272196)
Breast Cancer Res Treat. 2013 May;139(1):237-43. (PMID: 23605085)
J Natl Cancer Inst. 2010 Aug 18;102(16):1224-37. (PMID: 20616353)
Breast Cancer. 2018 Jan;25(1):100-107. (PMID: 28822078)
Eur J Cancer. 2013 Feb;49(3):703-9. (PMID: 23040889)
Nature. 2000 Aug 17;406(6797):747-52. (PMID: 10963602)
Br J Cancer. 1995 Aug;72(2):480-4. (PMID: 7640236)
Asian Pac J Cancer Prev. 2018 Jul 27;19(7):1767-1770. (PMID: 30049185)
Am J Pathol. 1980 Aug;100(2):497-512. (PMID: 6773421)
BMC Cancer. 2018 Feb 7;18(1):161. (PMID: 29415671)
Lancet. 2004 Mar 27;363(9414):1007-16. (PMID: 15051280)
Lancet Oncol. 2014 Jun;15(7):e279-89. (PMID: 24872111)
Breast Cancer Res Treat. 2016 Oct;159(3):395-406. (PMID: 27562585)
J Clin Oncol. 2005 Mar 1;23(7):1390-400. (PMID: 15735115)
Med Oncol. 2010 Sep;27(3):926-31. (PMID: 19771534)
Ann Surg. 2004 Feb;239(2):232-7. (PMID: 14745331)
NPJ Breast Cancer. 2018 Feb 6;4:3. (PMID: 29423438)
Cold Spring Harb Perspect Biol. 2011 Feb 01;3(2):. (PMID: 21047916)
Cancer Res. 1990 Dec 1;50(23):7415-21. (PMID: 2174724)
J Clin Oncol. 2017 Sep 10;35(26):3039-3045. (PMID: 28445098)
Eur J Cancer. 2005 Mar;41(4):590-600. (PMID: 15737565)
Breast Cancer Res Treat. 2017 Aug;165(1):193-200. (PMID: 28578505)
Cancer Res. 2000 Jul 15;60(14):3744-8. (PMID: 10919644)
Cancer Lett. 2017 Aug 10;401:63-71. (PMID: 28476483)
Int J Cancer. 1998 Nov 9;78(4):410-4. (PMID: 9797126)
Nature. 1983 Jun 30;303(5920):767-70. (PMID: 6866078)
Br J Cancer. 2002 Nov 18;87(11):1234-45. (PMID: 12439712)
Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):1053-60. (PMID: 14578142)
CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593)
Cancer Epidemiol Biomarkers Prev. 2017 Oct;26(10):1487-1492. (PMID: 28698184)
CA Cancer J Clin. 2017 Jan;67(1):7-30. (PMID: 28055103)
Int J Surg. 2014;12(5):394-8. (PMID: 24657350)
Am J Surg Pathol. 2009 May;33(5):759-67. (PMID: 19252432)
J Clin Oncol. 2010 Jun 1;28(16):2784-95. (PMID: 20404251)
Breast Cancer Res Treat. 2016 Apr;156(3):473-483. (PMID: 27041335)

2016YFC1303002 International National Key Research and special development project of China; 17-230-9-07 International Shenyang Science and Technology Plan Project of China

Keywords: advanced stage; breast cancer; early stage; molecular subtypes

0 (Receptors, Estrogen)
0 (Receptors, Progesterone)
EC 2.7.10.1 (ERBB2 protein, human)
EC 2.7.10.1 (Receptor, ErbB-2)

Date Created: 20191024 Date Completed: 20200924 Latest Revision: 20210110

20250114

PMC6885867

10.1002/cam4.2589

31642614