Chronic Fluoride Exposure and the Risk of Autism Spectrum Disorder.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE

Original Publication: Basel : MDPI, c2004-

Autism Spectrum Disorder/*etiology ; Fluorides/*toxicity ; Neurotoxicity Syndromes/*etiology; Animals ; Autism Spectrum Disorder/epidemiology ; Environmental Exposure/adverse effects ; Humans ; Neurotoxicity Syndromes/epidemiology ; Risk Factors

The continuous rise of autism spectrum disorder (ASD) prevalent in the past few decades is causing an increase in public health and socioeconomic concern. A consensus suggests the involvement of both genetic and environmental factors in the ASD etiopathogenesis. Fluoride (F) is rarely recognized among the environmental risk factors of ASD, since the neurotoxic effects of F are not generally accepted. Our review aims to provide evidence of F neurotoxicity. We assess the risk of chronic F exposure in the ASD etiopathology and investigate the role of metabolic and mitochondrial dysfunction, oxidative stress and inflammation, immunoexcitotoxicity, and decreased melatonin levels. These symptoms have been observed both after chronic F exposure as well as in ASD. Moreover, we show that F in synergistic interactions with aluminum's free metal cation (Al ³⁺ ) can reinforce the pathological symptoms of ASD. This reinforcement takes place at concentrations several times lower than when acting alone. A high ASD prevalence has been reported from countries with water fluoridation as well as from endemic fluorosis areas. We suggest focusing the ASD prevention on the reduction of the F and Al ³⁺ burdens from daily life.

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Keywords: ASD prevalence; aluminum; autism spectrum disorder; chronic fluoride exposure; endemic fluorosis; immunoexcitotoxicity; neurotoxicity; socioeconomic status; water fluoridation

Q80VPU408O (Fluorides)

Date Created: 20190919 Date Completed: 20200128 Latest Revision: 20231014

20240628

PMC6765894

10.3390/ijerph16183431

31527457