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Sub-Tenon Sustained Controllable Delivery of Dexamethasone for Treating Severe Acute Experimental Uveitis.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5078 (Electronic) Linking ISSN: 09273948 NLM ISO Abbreviation: Ocul Immunol Inflamm Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Buren, The Netherlands : Aeolus Press, c1993-
    • الموضوع:
      Disease Models, Animal* ; Drug Delivery Systems*; Dexamethasone/*administration & dosage ; Glucocorticoids/*administration & dosage ; Tenon Capsule/*drug effects ; Uveitis/*drug therapy; Acute Disease ; Animals ; Delayed-Action Preparations ; Female ; Flow Cytometry ; Male ; Mycobacterium tuberculosis ; Rabbits ; Slit Lamp Microscopy ; Uveitis/diagnosis
    • نبذة مختصرة :
      Purpose: To evaluate the efficacy of dexamethasone (DXM) through sub-tenon sustained controllable drug delivery system (SSCDDS) for treating severe acute experimental uveitis.
      Methods: Rabbits were treated with either DXM (treated group) or normal saline (control group) through SSCDDS. Clinical signs of uveitis were assessed at days 1, 3, 5, 7, and 14 after treatment. Histopathologic examinations were performed to evaluate inflammatory cell infiltration on posttreatment days 7 and 14.
      Results: All signs of experimental uveitis were reduced by SSCDDS of DXM according to clinical criteria, and the treated group had significantly less inflammation than the control group ( p <0.05). Histopathologic examinations showed severe inflammation and marked inflammatory cell infiltration in the control group, but minimal inflammation in the treated group.
      Conclusions: Sub-tenon sustained controllable delivery of DXM effectively suppresses severe acute inflammation in a rabbit model of uveitis. The proposed minimal invasive system might be a promising candidate for managing severe ocular diseases.
    • Contributed Indexing:
      Keywords: Dexamethasone; drug delivery system; sub-tenon; treatment; uveitis
    • الرقم المعرف:
      0 (Delayed-Action Preparations)
      0 (Glucocorticoids)
      7S5I7G3JQL (Dexamethasone)
    • الموضوع:
      Date Created: 20190821 Date Completed: 20210716 Latest Revision: 20210716
    • الموضوع:
      20221213
    • الرقم المعرف:
      10.1080/09273948.2019.1643027
    • الرقم المعرف:
      31429619