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A retrospective study: Clinicopathological and immunohistochemical analysis of 54 cases of tufted angioma.

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  • المؤلفون: Su X;Su X; Liu Y; Liu Y; Liu Y; Liu Y; Ma C; Ma C
  • المصدر:
    Indian journal of dermatology, venereology and leprology [Indian J Dermatol Venereol Leprol] 2020 Jan-Feb; Vol. 86 (1), pp. 24-32.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Scientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists Country of Publication: United States NLM ID: 7701852 Publication Model: Print Cited Medium: Internet ISSN: 0973-3922 (Electronic) Linking ISSN: 03786323 NLM ISO Abbreviation: Indian J Dermatol Venereol Leprol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2021- : Pittsford, NY : Scientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists
      Original Publication: Vellore, Indian Assn. of Dermatologists, Venereologists and Leprologists.
    • الموضوع:
      Hemangioma/*metabolism ; Hemangioma/*pathology ; Skin Neoplasms/*metabolism ; Skin Neoplasms/*pathology; Adolescent ; Child ; Child, Preschool ; China ; Female ; Hemangioma/complications ; Humans ; Infant ; Male ; Retrospective Studies ; Skin Neoplasms/complications ; Young Adult
    • نبذة مختصرة :
      Background: Tufted angioma is a rare benign lesion with vascular proliferation.
      Aim: To retrospectively analyze the clinicopathological manifestations and immunohistochemical features of tufted angioma.
      Methods: Clinical and histopathological features of tufted angioma (n = 54) were evaluated and analyzed retrospectively in the Department of Dermatology, Xijing Hospital from 2003 to 2014.
      Results: Clinically, tufted angioma usually presented as erythematous plaques and papules on the head and neck (n = 11), trunk (n = 21) and extremities (n = 22), mainly in children (n = 48), without gender difference (24 males and 30 females). A total of 45 cases showed solitary lesions and nine cases showed multiple lesions. Common symptoms included pain (n = 11), tenderness (n = 7), itching (n = 1), hypertrichosis (n = 7), hyperhidrosis (n = 6) and Kasabach-Merritt phenomenon (n = 1). Histopathologically, typical tufted angioma (n = 37) showed proliferation of endothelial cells in a so-called cannonball pattern, while in the early (n = 4) and regressed (n = 13) stages the tufted appearance was not prominent. The proliferated endothelial cells were diffusely positive for CD31 and Wilms tumor 1, focally positive for D2-40 and Prox1, and negative for Glut-1.
      Limitations: Our research was confined to patients of Chinese origin and our sample size was limited.
      Conclusions: Tufted angioma is a rare vascular neoplasm with diverse clinical manifestations and unique pathological features. It should be recognized as a vascular tumor with lymphatic differentiation. We emphasize the importance of considering tufted angioma in the differential diagnoses of any congenital or acquired vascular tumor.
      Competing Interests: None
    • Contributed Indexing:
      Keywords: Hemangioma; pathology; tufted angioma
    • الموضوع:
      Tufted angioma
    • الموضوع:
      Date Created: 20190810 Date Completed: 20200713 Latest Revision: 20220412
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.4103/ijdvl.IJDVL_777_18
    • الرقم المعرف:
      31397400