Allergic contact dermatitis in atopic individuals: Results of a 30-year retrospective study.

Publisher: Wiley Country of Publication: England NLM ID: 7604950 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0536 (Electronic) Linking ISSN: 01051873 NLM ISO Abbreviation: Contact Dermatitis Subsets: MEDLINE

Publication: <2005-> : Oxford : Wiley
Original Publication: Copenhagen, Munksgaard.

Allergens/*adverse effects ; Dermatitis, Allergic Contact/*epidemiology ; Dermatitis, Allergic Contact/*etiology ; Dermatitis, Atopic/*epidemiology; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Benzoquinones/adverse effects ; Case-Control Studies ; Child ; Child, Preschool ; Cobalt/adverse effects ; Dermatitis, Atopic/drug therapy ; Dermatologic Agents/adverse effects ; Female ; Humans ; Infant ; Infant, Newborn ; Lactones/adverse effects ; Male ; Middle Aged ; Nickel/adverse effects ; Prevalence ; Retrospective Studies ; Sesquiterpenes/adverse effects ; Young Adult

Background: The association between atopic dermatitis (AD) and contact allergy, remains unclear, with studies to date showing conflicting results.
Objectives: To investigate the prevalence of contact allergy in AD individuals compared to those without AD.
Methods: Results of 46 250 patients patch tested in a single centre over a span of 30 years were reviewed, comparing those with AD with those without AD. Collected data were analysed with corrections for multiple confounding variables, including date of patch testing to account for changes in allergens tested over the period.
Results: Nine allergens showed a statistically significant difference between the two groups. Contact allergy to nickel, cobalt and primin was less likely to arise in those with AD, whilst substances found in topical dermatological products were more likely to be associated with AD.
Conclusions: This is the largest single centre study of contact sensitization in atopy reported to date. The previously reported association between contact allergy to sesquiterpene lactone and AD is reinforced. The decreased incidence of metal allergy suggests distinct immunological effector mechanisms in sensitization to these allergens. In keeping with previous publications, exposure to topical treatments for AD can result in sensitisation and contact allergy and clinicians should consider patch testing in AD individuals who report worsening of their skin despite continued treatment with topical medicaments.
(© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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Keywords: allergic contact dermatitis; atopic dermatitis; contact allergy; contact dermatitis

0 (Allergens)
0 (Benzoquinones)
0 (Dermatologic Agents)
0 (Lactones)
0 (Sesquiterpenes)
3G0H8C9362 (Cobalt)
580KA9SG8W (primin)
7OV03QG267 (Nickel)

Date Created: 20190727 Date Completed: 20200505 Latest Revision: 20200505

20231215

10.1111/cod.13363

31347185