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Differential effects of slow rewarming after cerebral hypothermia on white matter recovery after global cerebral ischemia in near-term fetal sheep.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Hypothermia, Induced*; Brain/*embryology ; Brain Ischemia/*therapy ; Rewarming/*methods ; White Matter/*physiology; Animals ; Blood Gas Analysis ; Brain Ischemia/physiopathology ; Female ; Hypoxia-Ischemia, Brain/physiopathology ; Hypoxia-Ischemia, Brain/therapy ; Male ; Pregnancy ; Sheep ; White Matter/cytology
    • نبذة مختصرة :
      It is widely believed that rewarming slowly after therapeutic hypothermia for hypoxic-ischemic (HI) encephalopathy can improve outcomes, but its impact on white matter injury after HI is unclear. Fetal sheep (0.85 gestation) received 30 min ischemia-normothermia (n = 8), or hypothermia from 3-48 h with rapid spontaneous rewarming over 1 h (ischemia-48 h hypothermia, n = 8), or 48 h with slow rewarming over 24 h (ischemia-slow rewarming, n = 7) or 72 h with rapid rewarming (ischemia-72 h hypothermia, n = 8). Ischemia was associated with loss of total and mature oligodendrocytes and reduced area fraction of myelin basic protein (MBP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase; immature/mature oligodendrocytes) and increased microglia and astrocytes. Total numbers of oligodendrocytes were increased by all hypothermia protocols but only ischemia-72 h hypothermia attenuated loss of mature oligodendrocytes. All hypothermia protocols similarly increased the area fraction of MBP, whereas there was only an intermediate effect on the area fraction of CNPase. Microglia were suppressed by all hypothermia protocols, with the greatest reduction after ischemia-72 h hypothermia, and an intermediate effect after ischemia-slow rewarming. By contrast, induction of astrocytes was significantly reduced only after ischemia-slow rewarming. In conclusion, slow rewarming after hypothermia did not improve oligodendrocyte survival or myelination or suppression of microgliosis compared to fast rewarming, but modestly reduced astrocytosis.
    • References:
      Pediatrics. 1998 Nov;102(5):1098-106. (PMID: 9794940)
      J Cereb Blood Flow Metab. 2018 Jun;38(6):1047-1059. (PMID: 28504050)
      Sci Rep. 2016 Apr 28;6:25178. (PMID: 27121655)
      Curr Drug Targets. 2013 Jan 1;14(1):36-46. (PMID: 23170795)
      J Pediatr. 2012 Nov;161(5):799-807. (PMID: 22682614)
      Lancet. 2005 Feb 19-25;365(9460):663-70. (PMID: 15721471)
      J Cereb Blood Flow Metab. 2015 May;35(5):781-93. (PMID: 25564240)
      Neuroscience. 2016 Mar 1;316:296-310. (PMID: 26739327)
      J Cereb Blood Flow Metab. 2019 Nov;39(11):2246-2257. (PMID: 30092709)
      Kobe J Med Sci. 2003;49(3-4):83-91. (PMID: 14970751)
      J Cereb Blood Flow Metab. 1999 Jul;19(7):742-9. (PMID: 10413028)
      J Cereb Blood Flow Metab. 2004 Aug;24(8):877-86. (PMID: 15362718)
      J Clin Invest. 1997 Jan 15;99(2):248-56. (PMID: 9005993)
      J Cereb Blood Flow Metab. 2011 Apr;31(4):991-3. (PMID: 21206507)
      J Child Neurol. 2019 Sep;34(10):556-566. (PMID: 31070085)
      Neurology. 2011 Jun 14;76(24):2055-61. (PMID: 21670434)
      BMJ. 2010 Feb 09;340:c363. (PMID: 20144981)
      J Physiol. 2018 Dec;596(23):5641-5654. (PMID: 29660115)
      N Engl J Med. 2005 Oct 13;353(15):1574-84. (PMID: 16221780)
      Pediatr Res. 2010 Sep;68(3):205-9. (PMID: 20520585)
      Pediatrics. 2000 Jul;106(1 Pt 1):92-9. (PMID: 10878155)
      Pediatrics. 2004 Nov;114(5):1369. (PMID: 15520131)
      Glia. 2010 Jan 15;58(2):181-94. (PMID: 19606499)
      J Cereb Blood Flow Metab. 2015 May;35(5):751-8. (PMID: 25605291)
      Ann Neurol. 1992 Jan;31(1):14-21. (PMID: 1543346)
      Neuroimage Clin. 2017 Jun 10;15:572-580. (PMID: 28924555)
      Brain Res. 2010 Mar 10;1319:164-74. (PMID: 20079338)
      J Pediatr. 2015 Nov;167(5):987-93.e3. (PMID: 26387012)
      J Pediatr. 2005 Apr;146(4):453-60. (PMID: 15812446)
      Ann Neurol. 2012 Jan;71(1):121-32. (PMID: 22275258)
      Stroke. 1996 May;27(5):913-8. (PMID: 8623113)
    • الموضوع:
      Date Created: 20190714 Date Completed: 20201210 Latest Revision: 20210110
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC6626025
    • الرقم المعرف:
      10.1038/s41598-019-46505-0
    • الرقم المعرف:
      31300687