Serological evidence of Zika virus infection in non-human primates in Zambia.

Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE

Original Publication: Wien, New York, Springer-Verlag.

Zika Virus/*immunology ; Zika Virus Infection/*immunology ; Zika Virus Infection/*virology; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Cross Reactions/immunology ; Dengue Virus/immunology ; Flavivirus Infections/immunology ; Flavivirus Infections/virology ; Primates ; Serologic Tests/methods ; Zambia

Zika virus (ZIKV) circulation occurs between non-human primates (NHPs) in a sylvatic transmission cycle. To investigate evidence of flavivirus infection in NHPs in Zambia, we performed a plaque reduction neutralization test (PRNT) to quantify neutralizing antibodies. PRNT revealed that sera from NHPs (African green monkeys and baboons) exhibited neutralizing activity against ZIKV (34.4%; 33/96), whereas a PRNT for yellow fever virus using NHP sera showed no neutralization activity. ZIKV genomic RNA was not detected in splenic tissues from NHPs, suggesting that the presence of anti-ZIKV neutralizing antibodies represented resolved infections. Our evidence suggests that ZIKV is maintained in NHP reservoirs in Zambia.

0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)

Date Created: 20190603 Date Completed: 20190703 Latest Revision: 20190703

20231215

10.1007/s00705-019-04302-0

31154511