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Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.
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- معلومة اضافية
- المصدر:
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
- بيانات النشر:
Original Publication: San Francisco, CA : Public Library of Science, [2003]-
- الموضوع:
- نبذة مختصرة :
Cellular senescence is a driver of various aging-associated disorders, including osteoarthritis. Here, we identified a critical role for Yes-associated protein (YAP), a major effector of Hippo signaling, in maintaining a younger state of human mesenchymal stem cells (hMSCs) and ameliorating osteoarthritis in mice. Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR associated protein 9 nuclease (Cas9)-mediated knockout (KO) of YAP in hMSCs resulted in premature cellular senescence. Mechanistically, YAP cooperated with TEA domain transcriptional factor (TEAD) to activate the expression of forkhead box D1 (FOXD1), a geroprotective protein. YAP deficiency led to the down-regulation of FOXD1. In turn, overexpression of YAP or FOXD1 rejuvenated aged hMSCs. Moreover, intra-articular administration of lentiviral vector encoding YAP or FOXD1 attenuated the development of osteoarthritis in mice. Collectively, our findings reveal YAP-FOXD1, a novel aging-associated regulatory axis, as a potential target for gene therapy to alleviate osteoarthritis.
Competing Interests: The authors have declared that no competing interests exist.
- References:
Expert Opin Biol Ther. 2016;16(3):331-46. (PMID: 26593049)
Nature. 2011 Jun 08;474(7350):179-83. (PMID: 21654799)
Protein Cell. 2016 Mar;7(3):210-21. (PMID: 26874523)
Nat Commun. 2014;5:3197. (PMID: 24496101)
J Orthop Translat. 2017 Apr 12;9:89-103. (PMID: 29662803)
PLoS One. 2010 Oct 14;5(10):e13246. (PMID: 20976230)
Cell Res. 2016 Feb;26(2):190-205. (PMID: 26768768)
Biomed Pharmacother. 2019 Jan;109:2318-2326. (PMID: 30551490)
Izv Akad Nauk Ser Biol. 2006 Jan-Feb;(1):6-25. (PMID: 16521535)
Nat Protoc. 2009;4(12):1798-806. (PMID: 20010931)
Lab Invest. 2011 Dec;91(12):1739-52. (PMID: 21968810)
Biochem Biophys Res Commun. 2007 Jun 22;358(1):99-103. (PMID: 17482567)
Dev Cell. 2010 Oct 19;19(4):491-505. (PMID: 20951342)
Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838)
Bioinformatics. 2011 Apr 1;27(7):1017-8. (PMID: 21330290)
Cell Metab. 2017 Sep 5;26(3):460-474. (PMID: 28826795)
Science. 2014 Jan 3;343(6166):84-87. (PMID: 24336571)
Osteoarthritis Cartilage. 2006 Jan;14(1):13-29. (PMID: 16242352)
Nat Med. 2017 Sep;23(9):1072-1079. (PMID: 28825716)
Cell Rep. 2016 Feb 9;14(5):1169-1180. (PMID: 26832411)
Curr Opin Pharmacol. 2018 Jun;40:67-73. (PMID: 29625332)
Science. 2015 Dec 4;350(6265):1199-204. (PMID: 26785478)
Int J Mol Sci. 2015 Mar 16;16(3):6093-112. (PMID: 25785564)
Hum Gene Ther. 2018 Jan;29(1):2-14. (PMID: 29160173)
Int J Hematol. 2016 Feb;103(2):122-8. (PMID: 26692196)
Nat Med. 2017 Jun;23(6):775-781. (PMID: 28436958)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Biochem Biophys Res Commun. 2015 Jan 2;456(1):232-7. (PMID: 25462566)
J Endod. 2013 May;39(5):626-31. (PMID: 23611380)
Cell Stem Cell. 2011 Jan 7;8(1):31-45. (PMID: 21185252)
Genes Dev. 1996 Jun 15;10(12):1467-78. (PMID: 8666231)
Matrix Biol. 2014 Oct;39:44-9. (PMID: 25179676)
J Transl Med. 2014 Jan 07;12:8. (PMID: 24397850)
Arthritis Res. 2001;3(2):107-13. (PMID: 11178118)
Arthritis Rheum. 2004 May;50(5):1522-32. (PMID: 15146422)
Mech Ageing Dev. 2008 Mar;129(3):163-73. (PMID: 18241911)
Development. 2014 Jan;141(1):17-27. (PMID: 24284212)
Science. 2015 Jun 5;348(6239):1160-3. (PMID: 25931448)
Curr Opin Cell Biol. 2016 Dec;43:62-68. (PMID: 27592171)
Nat Med. 2018 Aug;24(8):1246-1256. (PMID: 29988130)
Osteoarthritis Cartilage. 2008 Jun;16(6):698-707. (PMID: 18255322)
Gene Ther. 2004 Feb;11(4):379-89. (PMID: 14724685)
Stem Cells. 2013 Mar;31(3):607-11. (PMID: 23193076)
Osteoarthritis Cartilage. 2017 Dec;25(12):2080-2090. (PMID: 28888901)
Arthritis Rheum. 2000 Jan;43(1):215-25. (PMID: 10643718)
Osteoarthritis Cartilage. 2001 May;9(4):308-15. (PMID: 11399094)
Genes Dev. 2008 Jul 15;22(14):1962-71. (PMID: 18579750)
Nat Methods. 2014 Aug;11(8):783-784. (PMID: 25075903)
Cell Signal. 2018 Apr;44:1-9. (PMID: 29284139)
Cell. 2015 Nov 5;163(4):811-28. (PMID: 26544935)
EMBO Rep. 2014 Jun;15(6):642-56. (PMID: 24825474)
Nat Commun. 2015 Dec 03;6:10068. (PMID: 26632666)
Tissue Eng Part A. 2009 Jul;15(7):1739-49. (PMID: 19119922)
Arthroscopy. 2013 Apr;29(4):748-55. (PMID: 23375182)
Cell Res. 2017 Sep;27(9):1178-1181. (PMID: 28685772)
Cell Res. 2017 Apr;27(4):483-504. (PMID: 28139645)
Acta Orthop. 2016 Dec;87(sup363):6-14. (PMID: 27658487)
Regen Ther. 2018 Nov 03;9:120-122. (PMID: 30525083)
Cell Discov. 2018 Jan 5;4:2. (PMID: 29423270)
J Cell Sci. 2004 Feb 29;117(Pt 6):889-97. (PMID: 14762107)
Genome Biol. 2013 Apr 25;14(4):R36. (PMID: 23618408)
Cell. 2016 Jun 2;165(6):1361-1374. (PMID: 27259148)
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S17-23. (PMID: 20864019)
Aging Cell. 2008 Jun;7(3):335-43. (PMID: 18248663)
Cell Stem Cell. 2019 Mar 7;24(3):447-461.e8. (PMID: 30661960)
J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):780-785. (PMID: 27516624)
Stem Cells. 2017 Aug;35(8):1958-1972. (PMID: 28589555)
Genome Res. 2012 Oct;22(10):1995-2007. (PMID: 22637570)
Protein Cell. 2019 Jun;10(6):417-435. (PMID: 30069858)
Nat Commun. 2015 Feb 19;6:6239. (PMID: 25695629)
Protein Cell. 2018 Apr;9(4):333-350. (PMID: 29476423)
Cytotechnology. 2015 Oct;67(5):793-807. (PMID: 24798808)
Nat Protoc. 2008;3(6):1032-45. (PMID: 18536650)
Front Immunol. 2013 Sep 04;4:201. (PMID: 24027567)
- الرقم المعرف:
0 (Adaptor Proteins, Signal Transducing)
0 (FOXD1 protein, human)
0 (Forkhead Transcription Factors)
0 (Transcription Factors)
0 (YAP-Signaling Proteins)
0 (YAP1 protein, human)
- الموضوع:
Date Created: 20190402 Date Completed: 20200106 Latest Revision: 20211204
- الموضوع:
20240628
- الرقم المعرف:
PMC6459557
- الرقم المعرف:
10.1371/journal.pbio.3000201
- الرقم المعرف:
30933975
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