FGF19 subfamily members: FGF19 and FGF21.

Publisher: Servicio de Publicaciones de la Universidad De Navarra (departamentos de fisiología y nutrición y de bioquimica) Country of Publication: Spain NLM ID: 9812509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-8755 (Electronic) Linking ISSN: 11387548 NLM ISO Abbreviation: J Physiol Biochem Subsets: MEDLINE

Original Publication: Pamplona, Spain : Servicio de Publicaciones de la Universidad De Navarra (departamentos de fisiología y nutrición y de bioquimica), [1998-

Fibroblast Growth Factors/*metabolism; Adipose Tissue/metabolism ; Animals ; Bile Acids and Salts/metabolism ; Carbohydrate Metabolism ; Cholecalciferol/metabolism ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/physiopathology ; Fibroblast Growth Factor-23 ; Glucuronidase/metabolism ; Humans ; Klotho Proteins ; Lipid Metabolism ; Obesity/metabolism ; Obesity/physiopathology ; Phosphorus/metabolism ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Vascular Diseases/metabolism

Fibroblast growth factors (FGF) constitute a large family of proteins with pleiotropic effects on development, organogenesis, and metabolism. The FGF19 subclass includes growth factors circulating with the blood referred to as endocrine FGF. Representatives of the FGF19 subclass, including FGF19, FGF21, and FGF23, act via FGFR receptors. The proteins of FGF19 subfamily influence the enterohepatic circulation of bile, participate in glucose and lipid metabolism regulation, and maintenance of phosphorus and vitamin D3 homeostasis. FGF19 and FGF21 are activated under different physiological and pathological conditions.

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Keywords: Bile acids; FGF19; FGF21; Klotho; Metabolism regulation

0 (Bile Acids and Salts)
0 (FGF19 protein, human)
0 (FGF23 protein, human)
0 (fibroblast growth factor 21)
1C6V77QF41 (Cholecalciferol)
27YLU75U4W (Phosphorus)
62031-54-3 (Fibroblast Growth Factors)
7Q7P4S7RRE (Fibroblast Growth Factor-23)
EC 2.7.10.1 (FGFR1 protein, human)
EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
EC 3.2.1.31 (Glucuronidase)
EC 3.2.1.31 (Klotho Proteins)

Date Created: 20190331 Date Completed: 20191220 Latest Revision: 20240718

20240718

PMC6611749

10.1007/s13105-019-00675-7

30927227