Hypolipidemic and antioxidant activities of volatile oils from fresh leaves of Michelia martini Levl.

Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Print ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE

Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988-

Antioxidants/*pharmacology ; Hypolipidemic Agents/*pharmacology ; Magnoliaceae/*chemistry ; Oils, Volatile/*pharmacology ; Plant Oils/*pharmacology; Amphotericin B/toxicity ; Animals ; Antioxidants/isolation & purification ; Biphenyl Compounds/chemistry ; CHO Cells ; Cricetulus ; Diet, High-Fat/adverse effects ; Dose-Response Relationship, Drug ; Hyperlipidemias/blood ; Hyperlipidemias/prevention & control ; Hypolipidemic Agents/isolation & purification ; Lipids/blood ; Male ; Oils, Volatile/isolation & purification ; Picrates/chemistry ; Plant Leaves/chemistry ; Plant Oils/isolation & purification ; Rats, Sprague-Dawley

.This study aimed to investigate the hypolipidemic and antioxidant activities of volatile oils from Michelia martini Levl. The antioxidant property of volatile oils from Michelia martini in vitro was investigated by establishment of various systems. High fat diet induced rats were used to assess the hypolipidemic and antioxidant activities of Michelia martini volatile oils in vivo. The level of total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, alanine transaminase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase in serum, and the activities of catalase, malondialdehyde, super oxide dismutase and glutathione in liver of rats were assayed by standard procedures. Our results showed that Michelia martini exhibits strong hypolipidemic and antioxidant activities both in vitro and vivo. Our data were also supplemented with histopathological studies on liver tissues and aorta sections of rats.

0 (Antioxidants)
0 (Biphenyl Compounds)
0 (Hypolipidemic Agents)
0 (Lipids)
0 (Oils, Volatile)
0 (Picrates)
0 (Plant Oils)
7XU7A7DROE (Amphotericin B)
DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)

Date Created: 20190311 Date Completed: 20190903 Latest Revision: 20190903

20250114

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