In the NAT era, is routine lookback to recipients still required when donors seroconvert for HIV infection?

Publisher: Blackwell Science Country of Publication: England NLM ID: 0413606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0410 (Electronic) Linking ISSN: 00429007 NLM ISO Abbreviation: Vox Sang Subsets: MEDLINE

Publication: 2001- : Oxford, UK : Blackwell Science
Original Publication: Basel : Karger

Blood Donors*; Blood Banks/*standards ; Blood Safety/*standards ; Donor Selection/*methods ; HIV Infections/*blood ; HIV Infections/*diagnosis; Blood Safety/methods ; Blood Transfusion/methods ; Blood Transfusion/standards ; England ; HIV Seropositivity/blood ; Humans ; Nucleic Acid Amplification Techniques ; Polymerase Chain Reaction ; Reproducibility of Results ; Wales

Human immuno virus screening assays have improved in sensitivity over the last 20 years and our data demonstrates that there is no evidence of missed HIV positive window period donations since the introduction of pooled HIV NAT screening. Here we recommend that extensive lookback investigations are not routinely required if the most recent negative donation is negative on individual sample HIV PCR testing.
(© 2019 International Society of Blood Transfusion.)

Keywords: blood safety; epidemiology; transfusion-transmissible infections

Date Created: 20190302 Date Completed: 20190722 Latest Revision: 20190722

20240829

10.1111/vox.12767

30820949