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Primary neurolymphomatosis of the trigeminal nerve.

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  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 8800054 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1360-046X (Electronic) Linking ISSN: 02688697 NLM ISO Abbreviation: Br J Neurosurg Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2015-: Abingdon, Oxfordshire : Taylor & Francis
      Original Publication: Abingdon, Oxfordshire : Carfax Pub. Co., c1987-
    • الموضوع:
      Neurolymphomatosis*/pathology ; Lymphoma, Large B-Cell, Diffuse*/diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse*/therapy; Male ; Humans ; Aged ; Trigeminal Nerve/diagnostic imaging ; Cranial Nerves ; Magnetic Resonance Imaging ; Facial Pain/pathology
    • نبذة مختصرة :
      We report a case of a primary malignant lymphoma of the trigeminal nerve that was associated with facial pain. A 65-year-old man was examined at another hospital for unilateral facial pain. Carbamazepine was prescribed, but his symptoms did not improve. Magnetic resonance imaging (MRI) revealed swelling of the trigeminal nerve and a mass lesion in Meckel's cave. The patient was referred to our hospital at this point. Gadolinium-enhanced MRI and F18-Fluorodeoxyglucose-position emission tomography suggested a likely malignant tumour and a biopsy was performed. Histopathological examination showed diffuse a large B cell lymphoma. The patient was treated with high-dose methotrexate (HD-MTX) and radiotherapy. Despite responding well to initial treatment, the patient relapsed, with lymphoma observed throughout the body. He died of pneumonia 18 months after the initial diagnosis. Facial pain is a symptom that is commonly managed in general practice. If symptoms do not improve, repeated imaging studies, including contrast MRI, is warranted. This is the first reported case of primary neurolymphomatosis (NL) of the trigeminal nerve associated with facial pain alone. Furthermore, HD-MTX and radiotherapy may be considered for the management of primary NL of a cranial nerve.
    • Contributed Indexing:
      Keywords: HD-MTX; Neurolymphomatosis; radiotherapy; trigeminal neuralgia
    • الموضوع:
      Date Created: 20190212 Date Completed: 20230707 Latest Revision: 20230718
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/02688697.2019.1568391
    • الرقم المعرف:
      30741017