Prospective Study of Psychological Morbidity and Illness Perceptions in Young People With Inflammatory Bowel Disease.

Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE

Publication: 2015- : Oxford : Oxford University Press
Original Publication: Amsterdam : Elsevier Science

Anxiety*/diagnosis ; Anxiety*/epidemiology ; Anxiety*/physiopathology ; Attitude to Health* ; Depression*/diagnosis ; Depression*/epidemiology ; Depression*/physiopathology ; Quality of Life*; Crohn Disease/*psychology; Adaptation, Psychological ; Adolescent ; Crohn Disease/diagnosis ; Crohn Disease/epidemiology ; Female ; Humans ; Male ; Patient Acuity ; Prevalence ; Risk Factors ; Self Concept ; Sex Factors ; United Kingdom/epidemiology ; Young Adult

Background and Aims: Psychological morbidity is increased in young people with inflammatory bowel disease [IBD]. Illness perceptions may be an important factor. This study aimed to describe the prevalence and severity of psychological morbidity and to examine relationships between baseline illness perceptions and anxiety, depression, and health-related quality of life [HRQoL], at baseline and 12 months later, in 16-21 year olds with IBD.
Methods: IBD patients [n = 121] completed measures of anxiety, depression, HRQoL, and illness perceptions [IPQ-R] at baseline and follow-up [n = 100, 83%].
Results: Among the 121 patients at baseline [median age 19.3 years, 40% female, 62% Crohn's disease, 73% in clinical remission], 55% reported elevated symptoms of anxiety/depression and 83% reported low HRQoL. Negative illness perceptions at baseline were significantly correlated with greater anxiety, depression, and lower HRQoL at baseline and follow-up. In regression analysis at baseline, the IPQ-R domain of greater perception of a cyclical nature of IBD was an independent predictor of anxiety, and a greater perceived emotional impact of IBD was an independent predictor of anxiety, depression, and HRQoL. Female gender and clinical relapse were also independent predictors of lower HRQoL. After controlling for baseline measures, clinical risk factors and illness perceptions did not explain additional variance in psychological morbidity at follow-up.
Conclusions: A high prevalence of psychological morbidity, stable over 1 year, was demonstrated in young people with IBD. Having negative illness perceptions, being female, and having active disease predicted those at greatest risk of psychological morbidity. Illness perceptions may be an appropriate target for psychological interventions.
(Copyright © 2019 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Keywords: Inflammatory bowel disease; paediatrics; psychological endpoints

Date Created: 20190206 Date Completed: 20200130 Latest Revision: 20200130

20231215

10.1093/ecco-jcc/jjz028

30722006