Distinct evolutionary origins of common multi-drug resistance phenotypes in Salmonella typhimurium DT104: a convergent process for adaptation under stress.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101093320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1617-4623 (Electronic) Linking ISSN: 16174623 NLM ISO Abbreviation: Mol Genet Genomics Subsets: MEDLINE

Original Publication: Berlin : Springer-Verlag, c2001-

Evolution, Molecular* ; Stress, Physiological*; Adaptation, Physiological/*genetics ; Drug Resistance, Multiple, Bacterial/*genetics ; Salmonella typhimurium/*genetics; Adaptation, Physiological/drug effects ; Anti-Bacterial Agents/pharmacology ; Base Sequence ; Drug Resistance, Multiple, Bacterial/drug effects ; Genes, Bacterial/genetics ; Genome, Bacterial/genetics ; Phylogeny ; Plasmids/classification ; Plasmids/genetics ; Salmonella typhimurium/classification ; Salmonella typhimurium/drug effects ; Sequence Homology, Nucleic Acid

Antimicrobial resistance makes pathogenic bacteria hard to control, but little is known about the general processes of resistance gain or loss. Here, we compared distinct S. typhimurium DT104 strains resistant to zero, two, five, or more of the tested antimicrobials. We found that common resistance phenotypes could be encoded by distinct genes, on SGI-1 or plasmid. We also demonstrated close clonality among all the tested non-resistant and differently resistant DT104 strains, demonstrating dynamic acquisition or loss (by total deletion or gradual decaying of multi-drug resistance gene clusters) of the genetic traits. These findings reflect convergent processes to make the bacteria resistant to multiple antimicrobials by acquiring the needed traits from stochastically available origins. When the antimicrobial stress is absent, the resistance genes may be dropped off quickly, so the bacteria can save the cost for maintaining unneeded genes. Therefore, this work reiterates the importance of strictly controlled use of antimicrobials.

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NSFC31600001 National Natural Science Foundation of China; NSFC81030029 National Natural Science Foundation of China; NSFC81271786 National Natural Science Foundation of China; NSFC81671980 National Natural Science Foundation of China; 2016M600266 Postdoctoral Research Foundation of China; 256177 Genome Canada

Keywords: Antimicrobial resistance; Convergent process; DT104; P972816; Pathogenic evolution; SGI-1; Salmonella typhimurium

0 (Anti-Bacterial Agents)

Date Created: 20190203 Date Completed: 20190603 Latest Revision: 20200225

20221213

10.1007/s00438-019-01531-5

30710177