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Incorporation of ifosfamide into various essential oils -based nanoemulsions ameliorates its apoptotic effect in the cancers cells.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Drug Compounding*; Apoptosis/*drug effects ; Breast Neoplasms/*pathology ; Ifosfamide/*pharmacology ; Nanoparticles/*chemistry ; Oils, Volatile/*chemistry ; Uterine Cervical Neoplasms/*pathology; Antineoplastic Agents, Alkylating/pharmacology ; Breast Neoplasms/drug therapy ; Cell Proliferation ; Emulsions ; Female ; Humans ; Nanoparticles/administration & dosage ; Tumor Cells, Cultured ; Uterine Cervical Neoplasms/drug therapy
    • نبذة مختصرة :
      The chemotherapeutic drugs, loaded in nanocarriers, have recently attracted the pharmaceutical industries due to their limited adverse side effects. The objective of the current study was to incorporate the ifosfamide (IFO) into two different essential oils-based nanoemulsions, lemon (LEM-IFO) and salvia (SAL-IFO). The antiproliferation activities of the resulted formulas were evaluated in the MCF-7 breast cancer cells and HeLa cervical cancers cells. The cytotoxic effect of the NE formulas was detected by the MTT assay, DAPI stain and light microscopy. The z-average diameters range of LEM-IFO and SAL-IFO, determined by the zetasizer, were 49.15-61.81 nm and 56.64-64.62 nm, respectively. The half maximal inhibitory concentration (IC 50 ) of LEM-IFO and SAL-IFO, applied into the HeLa cells, were 0.165 ± 0.025 and 0.141 ± 0.035 mM, respectively, whereas the IC 50 of LEM-IFO and SAL-IFO subjected into the MCF-7 cells were 0.200 ± 0.005 mM and 0.270 ± 0.025 mM, respectively. The IC 50 of the free IFO was markedly larger than LEM-IFO and SAL-IFO when applied into MCF-7 cells (9.20 ± 2.01 mM) and HeLa cells (7.69 ± 1.88 mM). Among the tested formulas, LEM-IFO and SAL-IFO have the greatest apoptotic effect on the MCF-7 and HeLa cells, respectively. Solubilizing the IFO in the essential oils-based NE has ameliorated the antitumor efficacy of IFO.
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    • الرقم المعرف:
      0 (Antineoplastic Agents, Alkylating)
      0 (Emulsions)
      0 (Oils, Volatile)
      UM20QQM95Y (Ifosfamide)
    • الموضوع:
      Date Created: 20190126 Date Completed: 20200813 Latest Revision: 20200813
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC6346000
    • الرقم المعرف:
      10.1038/s41598-018-37048-x
    • الرقم المعرف:
      30679649