Temporal trends in the birth rates and perinatal mortality of twins: A population-based study in China.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Birth Rate* ; Infant Mortality* ; Twins, Dizygotic* ; Twins, Monozygotic*; Stillbirth/*epidemiology; China/epidemiology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Pregnancy ; Retrospective Studies ; Rural Population ; Socioeconomic Factors ; Urban Population

Objective: Until now, little was known about the epidemiological characteristics of twins in China due to a lack of reliable national data. In this study, we aimed to analyze temporal trends and perinatal mortality of twins from China.
Methods: Data on twins between 2007 and 2014 were obtained from the China National Population-Based Birth Defects Surveillance System. Twin and singleton deliveries after at least 28 weeks of gestation were recruited and followed until postnatal day 42. Twinning rates were defined as the number of twin individuals per 1000 births(stillbirths and live births). The Weinberg's differential method was utilized to estimate the number of monozygotic and dizygotic twins.
Results: During 2007-2014, the twinning rate increased by 32.3% from 16.4 to 21.7 per 1000 total births with an average of 18.8‰. Among twins, both the perinatal mortality rate (26.1 per 1000 total births) and neonatal death rate (15.7 per 1000 live births) presented a downward tendency but remained at a high level. Large urban-rural and geographic disparities were identified in twinning rates, in perinatal and neonatal mortality, and in their temporal trends.
Conclusions: The upward trend of twinning rates in China paired with the relatively high rates of perinatal and neonatal mortality among twins highlights the need for improved perinatal care in the light of socio-demographic differences.
Competing Interests: The authors have declared that no competing interests exist.

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Date Created: 20190117 Date Completed: 20190923 Latest Revision: 20240606

20240606

PMC6334899

10.1371/journal.pone.0209962

30650106