Versatility of Cyclophilins in Plant Growth and Survival: A Case Study in Arabidopsis .

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, 2011-

Arabidopsis/*metabolism ; Arabidopsis Proteins/*metabolism ; Cyclophilins/*metabolism; Arabidopsis/growth & development ; Arabidopsis Proteins/genetics ; Cyclophilins/genetics ; Metabolic Networks and Pathways ; Plant Diseases/prevention & control ; Stress, Physiological

Cyclophilins (CYPs) belong to a peptidyl-prolyl cis-trans isomerase family, and were first characterized in mammals as a target of an immunosuppressive drug, cyclosporin A, preventing proinflammatory cytokine production. In Arabidopsis , 29 CYPs and CYP-like proteins are found across all subcellular compartments, involved in various physiological processes including transcriptional regulation, organogenesis, photosynthetic and hormone signaling pathways, stress adaptation and defense responses. These important but diverse activities of CYPs must be reflected by their versatility as cellular and molecular modulators. However, our current knowledge regarding their mode of actions is still far from complete. This review will briefly revisit recent progresses on the roles and mechanisms of CYPs in Arabidopsis studies, and information gaps within, which help understanding the phenotypic and environmental plasticity of plants.

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Keywords: Arabidopsis; Cyclophilin; PPlases; defense responses; organogenesis

0 (Arabidopsis Proteins)
EC 5.2.1.- (Cyclophilins)

Date Created: 20190113 Date Completed: 20190610 Latest Revision: 20200309

20250114

PMC6358970

10.3390/biom9010020

30634678