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Male infertility problems of patients with strict sperm morphology between 5-14% may be missed with the current WHO guidelines.

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  • معلومة اضافية
    • Corporate Authors:
      CopMich Collaborative
    • المصدر:
      Publisher: Medical Journals Sweden AB Country of Publication: Sweden NLM ID: 101587186 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2168-1813 (Electronic) Linking ISSN: 21681805 NLM ISO Abbreviation: Scand J Urol
    • بيانات النشر:
      Publication: 2023-: Uppsala, Sweden : Medical Journals Sweden AB
      Original Publication: Colchester, Esssex : Informa Healthcare
    • الموضوع:
      Hypogonadism/*diagnosis ; Infertility, Male/*diagnosis ; Spermatozoa/*pathology ; Teratozoospermia/*diagnosis ; Varicocele/*diagnosis; Adult ; Humans ; Infertility, Male/pathology ; Male ; Practice Guidelines as Topic ; Reference Values ; Semen Analysis ; Teratozoospermia/pathology ; World Health Organization
    • نبذة مختصرة :
      Objective: In 2010 W.H.O. changed the lower reference limit for strict sperm morphology from 15 to 4%. The change was based on 5 th percentile cut points from a meta-analysis on a published series of fertile men. This study investigates if patients referred for evaluation with sperm morphologies between 5-14% have identifiable etiologies of male infertility.
      Materials and Methods: I.R.B. approval was obtained to review records for patients referred to the University of Michigan Center of Reproductive Medicine between May 2012-May 2014 whom had a sperm morphology of 5-14%. Semen analysis, hormone levels, and information related to an infertility diagnosis, were recorded into a de-identified database. Patients were placed into the categories 'Varicocele', 'Hypogonadism', 'Intercourse problems', 'Anti-sperm antibodies (A.S.A.)', 'Other' or 'No diagnosis'.
      Results: A total of 253 patients were included in the study. Of these, 96/253 (38%) had a clinical varicocele; 44/253 (17%) hypogonadism; 4/253 (2%) intercourse problems; 11/253 (4%) evidence of sperm antibodies; and 15/253 (6%) had various other problems deemed potentially contributing causes of infertility. In all, nearly 67% of the subjects were identified to have a potential contributing etiology of male infertility. Similar results were found for the men with isolated low morphology (n = 194).
      Conclusions: This study demonstrates that 67% of men in infertile couples, who have strict sperm morphology between 5 and 14%, are found to have a potential contributing male factor infertility diagnosis. This raises the possibility that the new lower reference value for sperm morphology may result in missed opportunities for proper infertility assessment.
    • Contributed Indexing:
      Keywords: Male infertility; reference values; semen analysis
    • الموضوع:
      Date Created: 20190104 Date Completed: 20190812 Latest Revision: 20190812
    • الموضوع:
      20240628
    • الرقم المعرف:
      10.1080/21681805.2018.1548503
    • الرقم المعرف:
      30602328