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Concentration-time extrapolation of short-term inhalation exposure levels: dimethyl sulfide, a case study using a chemical-specific toxic load exponent.
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- المؤلفون: Demchuk E;Demchuk E; Ball SL; Ball SL; Le SL; Le SL; Prussia AJ; Prussia AJ
- المصدر:
Inhalation toxicology [Inhal Toxicol] 2018 Sep - Oct; Vol. 30 (11-12), pp. 448-462. Date of Electronic Publication: 2019 Jan 02.
- نوع النشر :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: Informa Healthcare Country of Publication: England NLM ID: 8910739 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-7691 (Electronic) Linking ISSN: 08958378 NLM ISO Abbreviation: Inhal Toxicol
- بيانات النشر:
Publication: London : Informa Healthcare
Original Publication: New York, N.Y. : Hemisphere Pub. Corp., c1989-
- الموضوع:
- نبذة مختصرة :
Objective: Dimethyl sulfide (DMS, CAS 75-18-3) is an industrial chemical. It is both an irritant and neurotoxicant that may be life-threatening because of accidental release. The effects of DMS on public health and associated public health response depend on the exposure concentration and duration. However, currently, public health advisory information exists for only a 1 h exposure duration, developed by the American Industrial Hygiene Association (AIHA). In the present work, the AIHA-reviewed data were computationally extrapolated to other common short-term durations.
Methods: The extrapolation was carried out using the toxic load equation, C n × t = TL, where C and t are exposure concentration and duration, TL is toxic load, and n is a chemical-specific toxic load exponent derived in the present work using probit meta-analysis. The developed threshold levels were vetted against the AIHA database of clinical and animal health effects induced by DMS.
Results: Tier-1 levels were derived based on human exposures that resulted in an easily detectable odor, because DMS is known to have a disagreeable odor that may cause nausea. Tier-2 levels were derived from the lower 95% confidence bounds on a benchmark concentration that caused 10% incidence (BMCL 10 ) of coma in rats during a 15 min inhalation exposure to DMS. Tier-3 levels were based on a BMCL 05 for mortality in rats.
Conclusion: Emergency responders and health assessors may consider these computationally derived threshold levels as a supplement to traditional chemical risk assessment procedures in instances where AIHA developed public health advisory levels do not exist.
- References:
Int J Legal Med. 1991;104(3):141-4. (PMID: 1911412)
Br Dent J. 2013 Apr;214(7):E20. (PMID: 23579164)
J Pharmacol Exp Ther. 1949 Jun;96(2):99-113. (PMID: 18152921)
Crit Rev Toxicol. 1991;21(3):183-208. (PMID: 2039594)
Mutat Res. 1993 Nov;303(3):127-33. (PMID: 7694129)
Am Ind Hyg Assoc J. 1984 Dec;45(12):787-90. (PMID: 6517022)
Regul Toxicol Pharmacol. 2005 Oct;43(1):45-54. (PMID: 16111795)
Nat Neurosci. 2014 Jan;17(1):114-20. (PMID: 24316890)
Met Ions Life Sci. 2014;14:279-313. (PMID: 25416398)
J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):71-88. (PMID: 7328716)
Regul Toxicol Pharmacol. 2010 Jun;57(1):124-8. (PMID: 20172012)
Mutat Res. 1990 Mar;229(1):11-5. (PMID: 2107398)
Enzymologia. 1969 Sep 30;37(3):163-73. (PMID: 4981448)
J Lab Clin Med. 1974 Jan;83(1):16-28. (PMID: 4808653)
Int J Toxicol. 2008;27(3):287-93. (PMID: 18569170)
- Grant Information:
CC999999 United States ImCDC Intramural CDC HHS
- Contributed Indexing:
Keywords: AEGL; ERPG; TLE; dimethyl sulfide; health guidance value; inhalation; inhalation exposure; n-value; toxic load; volatile organic compound
- الرقم المعرف:
0 (Air Pollutants)
0 (Irritants)
0 (Sulfides)
QS3J7O7L3U (dimethyl sulfide)
- الموضوع:
Date Created: 20190103 Date Completed: 20190820 Latest Revision: 20240402
- الموضوع:
20240402
- الرقم المعرف:
PMC8260034
- الرقم المعرف:
10.1080/08958378.2018.1551444
- الرقم المعرف:
30600740
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