Cytotoxic T cells in the lungs of mice infected with an influenza A virus.

Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0323767 Publication Model: Print Cited Medium: Print ISSN: 0300-9475 (Print) Linking ISSN: 03009475 NLM ISO Abbreviation: Scand J Immunol Subsets: MEDLINE

Publication: Oxford : Blackwell Scientific Publications
Original Publication: Oslo, Universitetsforlaget.

Cytotoxicity, Immunologic* ; Influenza A virus*; Lung/*immunology ; Respiratory Tract Infections/*immunology ; T-Lymphocytes/*immunology; Animals ; Antilymphocyte Serum/pharmacology ; Hemagglutination Inhibition Tests ; Injections ; Injections, Intravenous ; Lethal Dose 50 ; Mice ; Nose ; Splenectomy

Cytotoxic T cells are present in the lungs and the bronchoalveolar washings of mice infected intravenously (i.v.) or intranasally (i.n.) with live influenza A/WSN virus. After i.v. injection, cytotoxic T cell activity in both spleens and lungs reaches a peak at 6 days when the level of infectious virus recovered from the lungs falls sharply and the mice do not die. If a lethal dose of virus is given intranasally, very high levels of virus appear rapidly in the lungs, and the development of lung consolidation follows slightly behind the appearance of cytotoxic T cells there. When a non-lethal dose of virus is given intranasally, lower levels of virus are found in the lung and the appearance of cytotoxic T cells is delayed. These results suggest that the cytotoxic T cells play a protective role if the level of virus in the lungs does not reach very high levels. After injection of antithymocyte serum, the subsequent level of cytotoxic T cell activity in the lungs was greatly reduced, suggesting that the T cells recovered in lungs had at an earlier stage been circulating cells. However, splenectomized mice develop high levels of cytotoxic T cell activity, after intranasal infection of mice, indicating that the spleen did not contribute substantially to the T cells recovered in the lungs.

0 (Antilymphocyte Serum)

Date Created: 19780101 Date Completed: 19780517 Latest Revision: 20190818

20250114

10.1111/j.1365-3083.1978.tb00428.x

305613