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Association between antibiotic consumption and the rate of carbapenem-resistant Gram-negative bacteria from China based on 153 tertiary hospitals data in 2014.
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- المؤلفون: Yang P;Yang P; Chen Y; Chen Y; Jiang S; Jiang S; Shen P; Shen P; Lu X; Lu X; Xiao Y; Xiao Y
- المصدر:
Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2018 Nov 19; Vol. 7, pp. 137. Date of Electronic Publication: 2018 Nov 19 (Print Publication: 2018).
- نوع النشر :
Journal Article; Research Support, Non-U.S. Gov't
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: BioMed Central Country of Publication: England NLM ID: 101585411 Publication Model: eCollection Cited Medium: Internet ISSN: 2047-2994 (Electronic) Linking ISSN: 20472994 NLM ISO Abbreviation: Antimicrob Resist Infect Control Subsets: MEDLINE
- بيانات النشر:
Original Publication: London : BioMed Central
- الموضوع:
- نبذة مختصرة :
Background: This study aimed to investigate the relationship between the rate of carbapenem-resistant Gram-negative bacteria and antibiotic consumption intensity in 153 tertiary hospitals from China in 2014.
Methods: A retrospective study using national surveillance data from 2014 was conducted. Data on the annual consumption of each antibiotic, as well as the rate of carbapenem-resistant Gram-negative bacteria, were collected from each participating hospital, and the correlation between antibiotic consumption and carbapenem- resistant rate was analyzed.
Results: The overall antibiotic consumption intensity among the hospitals varied between 23.93 and 86.80 defined daily dosages (DDDs) per 100 patient-days (median, 46.30 DDDs per 100 patient-days). Cephalosporins were the most commonly used antibiotic, followed by quinolones, penicillins, and carbapenems, and the rate of carbapenem-resistant Gram-negative bacteria from each hospital varied. The correlations between carbapenem consumption intensity and rate of carbapenem resistance revealed correlation factors of 0.271 for Escherichia coli ( p < 0.01), 0.427 for Klebsiella pneumoniae ( p < 0.01), 0.463 for Pseudomonas aeruginosa ( p < 0.01), and 0.331 for Acinetobacter baumannii ( p < 0.01).
Conclusions: A significant relationship existed between the carbapenem consumption and the rates of carbapenem-resistant gram negative bacilli. Rational use of carbapenems should be implemented to address the issue of carbapenem resistance in hospitals.
Competing Interests: Given that this study was performed without accessing patient information, approval of the ethics committee was not required.Not applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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- Contributed Indexing:
Keywords: Acinetobacter baumannii; Carbapenem antibiotic consumption; Carbapenem-resistance; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa
- الرقم المعرف:
0 (Anti-Bacterial Agents)
0 (Carbapenems)
0 (Cephalosporins)
0 (Penicillins)
0 (Quinolones)
- الموضوع:
Date Created: 20181128 Date Completed: 20190930 Latest Revision: 20190930
- الموضوع:
20221213
- الرقم المعرف:
PMC6245771
- الرقم المعرف:
10.1186/s13756-018-0430-1
- الرقم المعرف:
30479750
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