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Evaluation of Serum Des-Gamma-Carboxy Prothrombin for the Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma: A Meta-Analysis.

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  • المؤلفون: Chen J;Chen J; Wu G; Wu G; Li Y; Li Y
  • المصدر:
    Disease markers [Dis Markers] 2018 Oct 04; Vol. 2018, pp. 8906023. Date of Electronic Publication: 2018 Oct 04 (Print Publication: 2018).
  • نوع النشر :
    Evaluation Study; Journal Article; Meta-Analysis
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: eCollection Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2015- : New York, NY : Hindawi Pub. Corp.
      Original Publication: Chichester ; New York : Wiley, c1983-
    • الموضوع:
      Biomarkers/*blood ; Biomarkers, Tumor/*blood ; Carcinoma, Hepatocellular/*blood ; Hepatitis B/*complications ; Liver Neoplasms/*blood ; Protein Precursors/*blood; Carcinoma, Hepatocellular/virology ; Humans ; Liver Neoplasms/virology ; Prothrombin ; Sensitivity and Specificity
    • نبذة مختصرة :
      Aim: To explore the diagnostic efficacy of des-gamma-carboxy prothrombin (DCP) in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC).
      Methods: A retrospective study of 459 cases from June 2016 to March 2018 was undertaken, and records of the DCP levels were extracted. The sensitivity, specificity, and cutoff points were calculated using SPSS 17.0 software. A systematic search in PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials was performed for articles published in English from 1997 to 2017, focusing on serum DCP for HBV-related HCC. Data on sensitivity, specificity, the positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were extracted from five studies by systematic search and one study of our own. The summary receiver operating characteristic (sROC) curve was obtained, and the area under the receiver operating characteristic (AUROC) curve was calculated.
      Results: The pooled sensitivity, specificity, PLR, NLR, and DOR were 0.71 (95% CI: 0.59, 0.80), 0.93 (95% CI: 0.87, 0.96), 9.5 (95% CI: 5.2, 17.5), 0.32 (95% CI: 0.22, 0.46), and 30 (95% CI: 13, 72), respectively. The AUROC curve was 0.91 (95% CI: 0.88, 0.93).
      Conclusions: In the diagnosis of HBV-related hepatocellular carcinoma (HCC), DCP is an ideal marker that should be considered for surveillance purposes.
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    • الرقم المعرف:
      0 (Biomarkers)
      0 (Biomarkers, Tumor)
      0 (Protein Precursors)
      53230-14-1 (acarboxyprothrombin)
      9001-26-7 (Prothrombin)
    • الموضوع:
      Date Created: 20181108 Date Completed: 20190218 Latest Revision: 20220331
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC6193331
    • الرقم المعرف:
      10.1155/2018/8906023
    • الرقم المعرف:
      30402170