Identification of antitumoral agents against human pancreatic cancer cells from Asteraceae and Lamiaceae plant extracts.

Publisher: BioMed Central Country of Publication: England NLM ID: 101088661 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6882 (Electronic) Linking ISSN: 14726882 NLM ISO Abbreviation: BMC Complement Altern Med Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-2019]

Antineoplastic Agents/*pharmacology ; Asteraceae/*chemistry ; Lamiaceae/*chemistry ; Pancreatic Neoplasms/*metabolism ; Plant Extracts/*pharmacology; Antineoplastic Agents/chemistry ; Caspases/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Fluorouracil ; Humans ; Plant Extracts/chemistry

Background: Pancreatic cancer is one of the most aggressive and mortal cancers. Although several drugs have been proposed for its treatment, it remains resistant and new alternatives are needed. In this context, plants and their derivatives constitute a relevant source of bioactive components which might efficiently inhibit tumor cell progression.
Methods: In this study, we have analyzed the potential anti-carcinogenic effect of different Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) plant extracts obtained by different green technologies (Supercritical CO 2 Extraction -SFE- and Ultrasonic Assisted Extraction -UAE-) to identify efficient plant extracts against human pancreatic cancer cells that could constitute the basis of novel treatment approaches.
Results: Asteraceae extracts showed better results as antitumoral agents than Lamiaceae by inducing cytotoxicity and inhibiting cell transformation, and SFE extracts were most efficient than UAE extracts. In addition, SFE derived plant extracts from Achillea millefolium and Calendula officinalis displayed synergism with the chemotherapeutic 5-Fluororacil.
Conclusion: These results show how Yarrow and Marigold SFE-derived extracts can inhibit pancreatic cancer cell growth, and could be proposed for a comprehensive study to determine the molecular mechanisms involved in their bioactivity with the final aim to propose them as potential adjuvants in pancreatic cancer therapy.

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MINECO/FEDER Plan Nacional I+D+i AGL2013- 48943-C2 Ministerio de Econom ıa y Competitividad del Gobierno de Espa~na; AGL2016-76736-C3-3-R) Ministerio de Econom ıa y Competitividad del Gobierno de Espa~na; P2013/ABI- 2728, ALIBIRD-CM Gobierno regional de la Comunidad de Madrid

Keywords: 5-Fluororacil; Asteraceae; Chemotherapeutic agents; Lamiaceae; Pancreatic cancer

0 (Antineoplastic Agents)
0 (Plant Extracts)
EC 3.4.22.- (Caspases)
U3P01618RT (Fluorouracil)

Date Created: 20180919 Date Completed: 20181012 Latest Revision: 20181114

20240829

PMC6142333

10.1186/s12906-018-2322-6

30223811