Ascites formation accompanied by portal vein thrombosis after porcine islet xenotransplantation via the portal vein in Rhesus macaque (Macaca mulatta).

Publisher: Munksgaard International Publishers Country of Publication: Denmark NLM ID: 9438793 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3089 (Electronic) Linking ISSN: 0908665X NLM ISO Abbreviation: Xenotransplantation Subsets: MEDLINE

Publication: Copenhagen : Munksgaard International Publishers
Original Publication: Copenhagen : Munksgaard, c1994-

Ascites/*complications ; Portal Vein/*transplantation ; Thrombosis/*complications ; Transplantation, Heterologous/*adverse effects; Animals ; Ascites/surgery ; Graft Rejection/etiology ; Graft Survival/physiology ; Islets of Langerhans Transplantation/methods ; Macaca mulatta ; Swine

Pig-to-nonhuman primate (NHP) islet transplantation has been widely conducted as a preclinical xenotransplantation model prior to human clinical trial. Portal vein thrombosis is one of the complications associated with islet infusion through the portal vein into the liver. Here, we briefly report severe case of ascites formation accompanied by portal vein thrombi after pig-to-NHP islet xenotransplantation in a rhesus monkey. Meticulous prophylactic treatment such as continuous heparin infusion should be implemented to prevent portal vein thrombi in pig-to-NHP islet transplantation models.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Keywords: ascites; porcine islet xenotransplantation; portal vein thrombus; rhesus monkey

Date Created: 20180909 Date Completed: 20190528 Latest Revision: 20190528

20231215

10.1111/xen.12460

30194788