Chemokine CXCL1 is responsible for cocaine-induced reward in mice.

Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101719700 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-173X (Electronic) Linking ISSN: 2574173X NLM ISO Abbreviation: Neuropsychopharmacol Rep Subsets: MEDLINE

Original Publication: [Hoboken, NJ] : John Wiley & Sons, Inc., [2018]-

Reward*; Chemokine CXCL1/*genetics ; Cocaine-Related Disorders/*metabolism; Animals ; Benzazepines/pharmacology ; Benzimidazoles/pharmacology ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Chemokine CXCL1/antagonists & inhibitors ; Chemokine CXCL1/metabolism ; Cocaine/pharmacology ; Cocaine-Related Disorders/physiopathology ; Dopamine Agonists/pharmacology ; Dopamine Uptake Inhibitors/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Phenylurea Compounds/pharmacology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism

Aim: We have previously demonstrated that upregulation of CC chemokines through dopamine receptor signaling in the prefrontal cortex (PFC) underlies methamphetamine (Meth)-induced reward. Given the common pharmacological property of Meth and cocaine (Coca), which are highly addictive psychostimulants, we hypothesized that chemokines may also contribute to Coca-induced reward. The aim of this study was to identify a key chemokine-mediating Coca-induced reward in mice.
Methods: The mRNA expression levels of chemokines were measured by reverse transcription-quantitative polymerase chain reaction. Coca-induced reward was evaluated by conditioned place preference test.
Results: We found that mRNA expression levels of CC chemokine ligand 2 (CCL2), CCL7, and CXC chemokine ligand 1 (CXCL1) were upregulated in the PFC after a single administration of Coca (20 mg/kg, s.c.). Upregulation of CXCL1, but not CCL2 and CCL7, mRNA in the PFC was also observed after repeated administration of Coca. A single administration of dopamine D1 receptor agonist SKF 81297 (10 mg/kg, s.c.), but not D2 receptor agonist sumanirole, upregulated CXCL1 mRNA in the PFC. Coca-induced reward was attenuated by the pretreatment of SB 225002 (5 mg/kg, s.c.), a selective antagonist of CXC chemokine receptor 2 (CXCR2, cognate receptor for CXCL1).
Conclusions: Collectively, we identified CXCL1 as a key regulator in Coca-induced reward and propose that pharmacological approach targeting CXCL1 could be a novel pharmacotherapy for Coca-induced reward.
(© 2018 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.)

Neuron. 2011 Feb 24;69(4):628-49. (PMID: 21338876)
J Pharmacol Sci. 2014;125(1):68-73. (PMID: 24748435)
Curr Top Med Chem. 2017;17(21):2440-2455. (PMID: 28474551)
Neuropsychopharmacol Rep. 2018 Sep;38(3):145-148. (PMID: 30175527)
PLoS One. 2015 Sep 28;10(9):e0139237. (PMID: 26414070)
Trends Pharmacol Sci. 2006 Jul;27(7):375-83. (PMID: 16762425)
Front Neural Circuits. 2013 Oct 11;7:152. (PMID: 24130517)
Neurosci Lett. 2018 Feb 5;665:33-37. (PMID: 29174638)
J Neuroinflammation. 2016 Jan 06;13:6. (PMID: 26738635)
Neuropsychopharmacology. 2002 Jan;26(1):130-4. (PMID: 11751040)
Neuroreport. 2000 Sep 11;11(13):2885-8. (PMID: 11006959)

Keywords: addiction; conditioned place preference test; dependence; dopamine receptor; prefrontal cortex

0 (Benzazepines)
0 (Benzimidazoles)
0 (Chemokine CCL2)
0 (Chemokine CXCL1)
0 (Dopamine Agonists)
0 (Dopamine Uptake Inhibitors)
0 (Phenylurea Compounds)
0 (RNA, Messenger)
0 (SB 225002)
2OI87T3R1B (U 95666E)
71636-61-8 (SK&F 81297)
I5Y540LHVR (Cocaine)

Date Created: 20180904 Date Completed: 20190918 Latest Revision: 20201209

20231215

PMC7292320

10.1002/npr2.12018

30175527