Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

A Novel Biomarker in Diabetic Macular Edema with Serous Retinal Detachment: Serum Chitinase-3-Like Protein 1.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 0054655 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0267 (Electronic) Linking ISSN: 00303755 NLM ISO Abbreviation: Ophthalmologica Subsets: MEDLINE
    • بيانات النشر:
      Publication: Basel : Karger
      Original Publication: Basel.
    • الموضوع:
      Visual Acuity*; Chitinase-3-Like Protein 1/*blood ; Diabetic Retinopathy/*blood ; Macular Edema/*blood ; Retina/*pathology ; Retinal Detachment/*etiology; Biomarkers/blood ; Case-Control Studies ; Cross-Sectional Studies ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Female ; Fluorescein Angiography/methods ; Follow-Up Studies ; Fundus Oculi ; Humans ; Macular Edema/complications ; Macular Edema/diagnosis ; Male ; Middle Aged ; Prospective Studies ; Retinal Detachment/blood ; Retinal Detachment/diagnosis ; Tomography, Optical Coherence/methods
    • نبذة مختصرة :
      Purpose: To determine whether serum chitinase-3-like protein 1 (CHI3L1) and interleukin-6 (IL-6) levels correlate with serous retinal detachment (SRD) in diabetic macular edema (DME) using spectral-domain optical coherence tomography (SD-OCT).
      Methods: In this cross-sectional case-control study, 394 patients (treatment-naive DME patients, n = 218; diabetic patients without DME, n = 96; nondiabetic controls, n = 80) were included in the study. Eyes were classified according to SD-OCT features of DME: SRD, cystoid macular edema (CMO), and diffuse retinal thickness (DRT). Serum concentrations of CHI3L1 and IL-6 were analyzed using enzyme-linked immunosorbent assay.
      Results: Serum CHI3L1 and IL-6 levels were significantly higher in DME with SRD compared to patients with CMO and DRT (p < 0.001 for all groups). Multivariate regression analysis showed that CHI3L1 and IL-6 had a stronger influence on the presence of SRD in DME (r = 1.162, p = 0.026, and r = 1.242, p = 0.016, respectively). Serum concentration of CHI3L1 was significantly correlated with that of IL-6 (r = 0.386, p = 0.0015).
      Conclusions: Our data suggest that serum concentrations of CHI3L1 and IL-6 are involved in the process of SRD in DME. CHI3L1 can be investigated further as a new diagnostic biomarker for DME with SRD.
      (© 2018 S. Karger AG, Basel.)
    • Contributed Indexing:
      Keywords: Chitinase-3-like protein 1; Diabetes mellitus; Diabetic macular edema; ELISA; Interleukin-6; Serum
    • الرقم المعرف:
      0 (Biomarkers)
      0 (Chitinase-3-Like Protein 1)
    • الموضوع:
      Date Created: 20180822 Date Completed: 20190306 Latest Revision: 20190306
    • الموضوع:
      20231215
    • الرقم المعرف:
      10.1159/000490534
    • الرقم المعرف:
      30130755