[Accidents in patients under anticoagulant therapy in the Department of Cardiology at the Yalgado Ouedraogo Teaching Hospital, Ouagadougou (Burkina Faso)].

Les accidents du traitement anticoagulant dans le Service de Cardiologie du Centre Hospitalier Universitaire Yalgado Ouedraogo de Ouagadougou (Burkina Faso).

Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE

Original Publication: Kampala, Uganda : African Field Epidemiology Network

Anticoagulants/*adverse effects ; Gastrointestinal Hemorrhage/*chemically induced ; Hemorrhage/*chemically induced ; Myocardial Infarction/*epidemiology; Adult ; Aged ; Anticoagulants/administration & dosage ; Antidotes/administration & dosage ; Antidotes/supply & distribution ; Burkina Faso ; Female ; Gastrointestinal Hemorrhage/epidemiology ; Hemorrhage/epidemiology ; Heparin, Low-Molecular-Weight/administration & dosage ; Heparin, Low-Molecular-Weight/adverse effects ; Hospitalization/statistics & numerical data ; Hospitals, Teaching ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Vitamin K/antagonists & inhibitors ; Young Adult

This study aimed to evaluate the profile of patients hospitalized for anticoagulant-induced hemorrhage. We conducted a retrospective, descriptive study within the Department of Cardiology at the Yalgado Ouedraogo Teaching Hospital, in Ouagadougou, over a period of 2 years from 1 January 2007 to 31 December 2008. All hospitalized patients with anticoagulant-induced hemorrhage were included in the study. The average age of patients was 49,31 ± 17,68 years, the sex-ratio was 2,17. Myocardial infarction was the first indication for anticoagulant treatment, with a rate of 21.05%. Anti vitamin K (AVK) was associated with hemorrhage in 63,16% (n=12) of patients versus 36,84% (n=7) of patients treated with low molecular weight heparins (LMWH); 10 patients had major hemorrhage while nine patients had minor hemorrhage. The average duration of Anti vitamin K (AVK) treatment was 16 ± 58 weeks. Hemorrhage in the digestive tract was the most frequent symptom (31,58%) and, in 89,47% of patients, treatment was associated with platelet aggregation. Treatment of hemorrhagic accident was based on definitive cessation of anticoagulant therapy in 73,68% of patients. Four patients (21.05%) died. The inaccessibility to antidotes such as protamine sulphate and PPSD (Prothrombin, Proconvertine, Stuart factor, and anti-haemophilia B factor) constitutes a real obstacle to adequate treatment for complications; a better education of patients receiving these drugs would be the most important preventive measure, because more than 50% of these accidents are preventable.

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Keywords: Anticoagulant; hemorrhage; venous thrombosis

0 (Anticoagulants)
0 (Antidotes)
0 (Heparin, Low-Molecular-Weight)
12001-79-5 (Vitamin K)

Date Created: 20180728 Date Completed: 20180827 Latest Revision: 20220330

20240628

PMC6057581

10.11604/pamj.2018.29.135.10650

30050599