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A novel strategy for in vivo angiogenesis and osteogenesis: magnetic micro-movement in a bone scaffold.

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  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2015- : Abingdon, Oxford : Taylor & Francis
      Original Publication: London : Informa Healthcare, [2013]-
    • الموضوع:
      Motion* ; Neovascularization, Physiologic*/genetics ; Osteogenesis*/genetics; Bone and Bones/*cytology ; Drug Carriers/*chemistry ; Magnetite Nanoparticles/*chemistry ; Tissue Scaffolds/*chemistry; Animals ; Bone and Bones/blood supply ; Bone and Bones/physiology ; Chitosan/chemistry ; Drug Liberation ; Magnetic Fields ; Plasmids/chemistry ; Plasmids/genetics ; Rabbits ; Tissue Engineering ; Transfection
    • نبذة مختصرة :
      Angiogenesis and osteogenesis in tissue-engineered bone are the key factors in the clinical application of tissue-engineering technology to repair large bone defects. In vivo cells that are farther than 200 μm from capillaries cannot survive due to lack of nutrients and oxygen, and thus, the tissue-engineered bone is not suitable for repairing large bone defects. In this study, we constructed a novel artificial bone scaffold loaded with superparamagnetic plasmid gene microspheres. Magnetic micro-movement of the magnetic microspheres in the scaffold was generated by an oscillating magnetic field and a static magnetic field to promote the release of plasmid genes from microspheres for transfection of surrounding cells, resulting in protein expression of vascular endothelial growth factor, thus promoting angiogenesis and osteogenesis in the scaffold, internal vascularization of the artificial bone scaffold and repair of large bone defects.
    • Contributed Indexing:
      Keywords: Magnetic micro-movement; VEGF; angiogenesis; gene delivery; magnetic field; scaffold
    • الرقم المعرف:
      0 (Drug Carriers)
      0 (Magnetite Nanoparticles)
      9012-76-4 (Chitosan)
    • الموضوع:
      Date Created: 20180724 Date Completed: 20190605 Latest Revision: 20190605
    • الموضوع:
      20240628
    • الرقم المعرف:
      10.1080/21691401.2018.1465947
    • الرقم المعرف:
      30033765