Graphene Oxide Quantum Dots Reduce Oxidative Stress and Inhibit Neurotoxicity In Vitro and In Vivo through Catalase-Like Activity and Metabolic Regulation.

Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: eCollection Cited Medium: Print ISSN: 2198-3844 (Print) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: PubMed not MEDLINE

Original Publication: Weinheim : WILEY-VCH, [2014]-

Both oxidative stress and neurotoxicity are huge challenges to human health, and effective methods and agents for resisting these adverse effects are limited, especially in vivo. It is shown here that, compared to large graphene oxide (GO) nanosheets, GO quantum dots (GOQDs), as nanozymes, efficiently reduce reactive oxygen species (ROS) and H 2 O 2 in 1-methyl-4-phenyl-pyridinium ion (MPP ⁺ )-induced PC12 cells. In addition, GOQDs exert neuroprotective effects in a neuronal cell model by decreasing apoptosis and α-synuclein. GOQDs also efficiently diminish ROS, apoptosis, and mitochondrial damage in zebrafish treated with MPP ⁺ . Furthermore, GOQDs-pretreated zebrafish shows increased locomotive activity and Nissl bodies in the brain, confirming that GOQDs ameliorate MPP ⁺ -induced neurotoxicity, in contrast to GO nanosheets. GOQDs contribute to neurotoxic amelioration by increasing amino acid metabolism, decreasing tricarboxylic acid cycle activity, and reducing steroid biosynthesis, fatty acid biosynthesis, and galactose metabolic pathway activity, which are related to antioxidation and neurotransmission. Meanwhile, H 2 O 2 decomposition and Fenton reactions suggest the catalase-like activity of GOQDs. GOQDs can translocate into zebrafish brains and exert catalase-mimicking activity to resist oxidation in the intracellular environment. Unlike general nanomaterials, biocompatible GOQDs demonstrate their high potential for human health by reducing oxidative stress and inhibiting neurotoxicity.

Biomaterials. 2017 Jul;131:121-130. (PMID: 28388498)
Nat Nanotechnol. 2012 Aug;7(8):530-5. (PMID: 22751222)
ACS Nano. 2016 Apr 26;10(4):4742-53. (PMID: 27035744)
Adv Mater. 2010 May 18;22(19):2206-10. (PMID: 20564257)
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. (PMID: 28096355)
Adv Mater. 2012 Apr 3;24(13):1722-8. (PMID: 22407491)
ACS Appl Mater Interfaces. 2017 Apr 5;9(13):11528-11536. (PMID: 28291324)
ACS Nano. 2015 Aug 25;9(8):7913-24. (PMID: 26207693)
J Am Chem Soc. 2012 Sep 12;134(36):14781-8. (PMID: 22889183)
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16970-5. (PMID: 20837543)
Angew Chem Int Ed Engl. 2013 May 3;52(19):4986-97. (PMID: 23580235)
ACS Chem Neurosci. 2013 Apr 17;4(4):575-84. (PMID: 23590250)
Environ Health Perspect. 2014 Mar;122(3):269-76. (PMID: 24362357)
Small. 2016 Aug;12(30):4127-35. (PMID: 27346719)
Biomaterials. 2016 Jul;93:83-94. (PMID: 27085073)
Environ Health Perspect. 2010 Apr;118(4):572-8. (PMID: 20368126)
ACS Appl Mater Interfaces. 2015 Aug 19;7(32):18104-12. (PMID: 26221973)
Environ Health Perspect. 2013 May;121(5):586-93. (PMID: 23425943)
ACS Nano. 2015 May 26;9(5):4850-71. (PMID: 25825926)
Adv Mater. 2016 Feb 17;28(7):1387-93. (PMID: 26643597)
Biomaterials. 2015 Apr;48:37-44. (PMID: 25701030)
Adv Sci (Weinh). 2018 Mar 04;5(5):1700595. (PMID: 29876205)
Exp Gerontol. 2017 Mar;89:20-29. (PMID: 28062370)
Environ Sci Technol. 2017 Jul 18;51(14):7861-7871. (PMID: 28614664)
Nanoscale. 2015 Dec 7;7(45):19060-5. (PMID: 26515666)
Exp Neurobiol. 2013 Jun;22(2):77-83. (PMID: 23833556)
Sci Adv. 2016 Jul 01;2(7):e1600014. (PMID: 27419232)
Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3719-E3728. (PMID: 28416692)
ACS Appl Mater Interfaces. 2017 Apr 12;9(14):12241-12252. (PMID: 28322544)
Toxicol Sci. 2017 Oct 1;159(2):422-435. (PMID: 28962526)
Protein Sci. 2003 Apr;12(4):702-7. (PMID: 12649428)
Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7319-7324. (PMID: 28655841)
Nat Med. 2017 Feb 7;23(2):1-13. (PMID: 28170377)
Sci Rep. 2013;3:2364. (PMID: 23917584)
Mol Neurobiol. 2017 Oct;54(8):6490-6506. (PMID: 27730512)
Adv Mater. 2013 Jul 26;25(28):3780-801. (PMID: 23722464)
Biomaterials. 2016 Mar;83:102-14. (PMID: 26773667)
Chem Soc Rev. 2012 Mar 21;41(6):2323-43. (PMID: 22170510)
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3815-9. (PMID: 26993805)
ACS Appl Mater Interfaces. 2016 Nov 9;8(44):30126-30132. (PMID: 27779401)
Nat Med. 2016 Feb;22(2):175-82. (PMID: 26726877)
Metab Brain Dis. 2017 Jun;32(3):811-817. (PMID: 28236040)
Antioxid Redox Signal. 2010 Jan;12(1):125-69. (PMID: 19624272)
Adv Funct Mater. 2018 Mar 21;28(12):. (PMID: 33867903)
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12295-300. (PMID: 23840061)
Sci Adv. 2017 Jun 21;3(6):e1603001. (PMID: 28691086)
Sci Transl Med. 2016 Dec 7;8(368):368ec196. (PMID: 27928022)
Nanotoxicology. 2016;10(4):426-35. (PMID: 26444998)
ACS Nano. 2012 May 22;6(5):4001-12. (PMID: 22533614)
Biomaterials. 2016 Oct;104:182-91. (PMID: 27454064)
Neuropharmacology. 2016 Feb;101:480-9. (PMID: 26525190)
Nanotoxicology. 2016;10(1):42-52. (PMID: 25704117)
ACS Nano. 2013 Aug 27;7(8):6858-67. (PMID: 23829293)
PeerJ. 2016 Dec 13;4:e2739. (PMID: 27994964)
Environ Health Perspect. 2016 Oct;124(10):1537-1546. (PMID: 27187980)
Biomed Environ Sci. 2015 May;28(5):341-51. (PMID: 26055561)
Nat Commun. 2017 Apr 04;8:14835. (PMID: 28374771)
J Am Chem Soc. 2014 Apr 9;136(14):5443-50. (PMID: 24625033)
ACS Nano. 2015 Jun 23;9(6):5713-24. (PMID: 26040772)
ACS Nano. 2016 Feb 23;10(2):2860-70. (PMID: 26844592)
Environ Health Perspect. 2016 Nov;124(11):1766-1775. (PMID: 27301718)
Nanoscale. 2014 Jun 7;6(11):5894-906. (PMID: 24756229)

Keywords: catalase‐like activity; graphene oxide; metabolomics; neuroprotection; quantum dots

Date Created: 20180608 Latest Revision: 20240326

20250114

PMC5978962

10.1002/advs.201700595

29876205