Insomnia mediates the longitudinal relationship between anxiety and depressive symptoms in a nationally representative sample of adolescents.

Publisher: Wiley Country of Publication: United States NLM ID: 9708816 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6394 (Electronic) Linking ISSN: 10914269 NLM ISO Abbreviation: Depress Anxiety Subsets: MEDLINE

Original Publication: New York, NY : Wiley, c1997-

Anxiety/*epidemiology ; Depression/*epidemiology ; Sleep Initiation and Maintenance Disorders/*epidemiology; Adolescent ; Adult ; Comorbidity ; Female ; Humans ; Longitudinal Studies ; Male ; United States/epidemiology

Background: Anxiety and depression are commonly comorbid with each other, with anxiety often temporally preceding the development of depression. Although increasingly research has begun to investigate the role of sleep problems in depression, no study has examined insomnia as a mediator in the longitudinal relationship between anxiety and subsequent depression.
Methods: The current study utilizes data from Waves I, II, and IV of the National Longitudinal Study of Adolescent to Adult Health, a nationally representative prospective study conducted over a 14-year period (n = 20,745, 50.5% female, M age at Wave I = 16.20). Participants completed portions of the Center for Epidemiologic Studies Depression Scale at Waves I and IV to assess depressive symptoms, a six-item anxiety measure at Wave I, and three items assessing insomnia, sleep quality, and sleep duration at Wave II.
Results: Structural equation modeling indicated that insomnia and unrestful sleep significantly mediated the relationship between anxiety and subsequent depression. The relationship between anxiety and depression was not significantly mediated by sleep duration.
Conclusions: Findings suggest that anxiety may increase risk for the development of later depression through insomnia.
(© 2018 Wiley Periodicals, Inc.)

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P01 HD031921 United States HD NICHD NIH HHS

Keywords: anxiety/anxiety disorders; child/adolescent; depression; mood disorders; sleep disorders

Date Created: 20180427 Date Completed: 20181026 Latest Revision: 20190610

20221213

PMC5992096

10.1002/da.22764

29697888